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http://dx.doi.org/10.4489/KJM.2013.41.2.97

Antioxidant and Anti-Inflammatory Activities of Methanol and Hot Water Extracts of Pholiota nameko Fruiting Bodies  

Nguyen, Trung Kien (Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University)
Shin, Do Bin (Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University)
Lee, Su Min (Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University)
Im, Kyung Hoan (Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University)
Lee, Tae Soo (Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University)
Lee, U Youn (Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University)
Publication Information
The Korean Journal of Mycology / v.41, no.2, 2013 , pp. 97-103 More about this Journal
Abstract
Pholiota nameko is an edible mushroom belonged to Family Strophariaceae of Agaricales, Basidiomycota. The purpose of this study was to investigate the antioxidant and anti-inflammatory activities for the methanol and hot water extracts prepared from fruiting bodies of Pholiota nameko. Besides measuring for 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, a reducing power and a chelating activity on ferrous ions were also measured to evaluate the antioxidant activity for those extracts. To measure the anti-inflammatory activities for the extracts, nitric oxide(NO) production from lipopolysaccharide treated RAW 264.7 macrophage cells and carrageenan-induced acute hind paw edema of rats were investigated. The results showed that those extracts has a excellent chelating activity on the ferrous ions compared with positive controls. And it also turned out that extracts had a good DPPH activity and a reducing power. The NO production in LPS-treated RAW 264.7 macrophage cells were decreasing as we increased concentration of those mushroom extracts. Significant reduction of paw edema were also observed at 2~6 h after we treated methanol and hot-water extracts at the 50 mg/kg concentration to the rats which are induced acute hind paw edema by carrageenan treatment. The experimental results suggested that methanol and hot-water extracts of Pholiota nameko fruiting bodies might be used for potential source of antioxidant and anti-inflammatory agents.
Keywords
anti-inflammation; antioxidant; mushroom fruiting body; Pholiota nameko;
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Times Cited By KSCI : 4  (Citation Analysis)
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