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http://dx.doi.org/10.4489/KJM.2010.39.3.194

Screening New Antihypertensive Angiotensin I-Converting Enzyme Inhibitor -Producing Yeast and Optimization of Production Condition  

Kang, Min-Gu (Department of Life Science and Genetic Engineering, Paichai University)
Kim, Ha-Kun (Department of Life Science and Genetic Engineering, Paichai University)
Yi, Sung-Hun (Korea Food Research Institute)
Lim, Sung-Il (Korea Food Research Institute)
Lee, Jong-Soo (Department of Life Science and Genetic Engineering, Paichai University)
Publication Information
The Korean Journal of Mycology / v.39, no.3, 2011 , pp. 194-197 More about this Journal
Abstract
Forty eight strains of yeast were cultured in potato dextorse(PD) broth at $30^{\circ}C$ for 24 hr and centrifuged with 12,000 rpm for 20 min. After concentrated the cultures, antihypertensive angiotensin I-converting enzyme(ACE) inhibitory activities of its concentrates were investigated. Among them, the concentrates from Saccharomyces cerevisiae Y183-3 showed the highest ACE inhibitory activity of 71.8%. The ACE inhibitor from Saccharomyces cerevisiae Y183-3 was maximally produced when Saccharomyces cerevisiae Y183-3 cultured in PD broth at $30^{\circ}C$ for 36 hr.
Keywords
Antihypertensive angiotensin I-converting enzyme inhibitor; Potato dextrose broth; Saccharomyces cerevisiae Y183-3;
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Times Cited By KSCI : 4  (Citation Analysis)
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1 Lee, D. H., Kim, J. H., Park, J. S., Choi, Y. J. and Lee, J. S. 2004. Isolation and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from the edible mushroom Tricholoma giganteum. Peptides 25:621-627.   DOI   ScienceOn
2 Maruyama, S., Miyoshi, S. and Tanaka, H. 1989. Angiotensin Iconverting enzyme inhibitor derived from Ficus carica. Agric. Biol. Chem. 53:2763-2769.   DOI
3 Rhyu, M. R., Nam, Y. I. and Lee, H. Y. 1996. Screening of angiotensin I-converting enzyme inhibitors in cereals and legumes. Food & Biotechnol. 5:334-337
4 Saito Y., Wanezaki, K., Kawato, A. and Imayasu, S. 1994. Structure and activity of angiotensin I-converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem. 58:1767-1771.   DOI   ScienceOn
5 Satio, Y., Nakamura, K., Kawato, A. and Imayasu, S. 1992. Angiotensin I-converting enzyme inhibitors in sake and its by products. Nippon Nogeikagakukaishi 66:1081-1087.   DOI
6 Soffer, R. L., 1976. Angiotensin I-converting enzyme and the regulation of vasoactive peptides. Annu. Rev. Biochem. 45:73-94.   DOI   ScienceOn
7 이대형, 김재호, 정종천, 공원식, 유영복, 박정식, 유창현, 이종수. 2003. 각종 버섯류로부터 안지오텐신 전환효소 저해제의 탐색. 한국균학회지. 31:148-154   과학기술학회마을   DOI   ScienceOn
8 김재호, 이대형, 최신양, 이종수. 2002. 전통민속주의 생리기능성 탐색. 한국식품과학회지. 34:118-122.   과학기술학회마을
9 Cushman D. W. and Cheung H.S. 1971. Spectrophotometic assay and properties of angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 20:1637-1648   DOI   ScienceOn
10 Ganong, W. F. 1997. Review od medical physiology. Appleton and Lange (New jersey, USA) pp. 425-460
11 Jang, J. H., Jeong, S. C., Kim, J. H., Lee, Y. H. Ju, Y. C. and Lee, J. S. 2011. Characterization of new antihypertensive angiotensin I-converting enzyme inhibitory peptide from Pleurotus cornucopiae. Food Chemistry 127:412-418   DOI   ScienceOn
12 Jeong, S. C., Kim, J. H., Kim, N. M. and Lee, J. S. 2005. Production of antihypertensive angiotensin I-converting enzyme inhibitor from Malassezia pachydermatis G-14. Myicobiol. 33:142-146.   DOI   ScienceOn
13 Koo, K. C., Lee, D. H., Kim, J. H., Yu, H. E., Park, J. S. and Lee, J. S. 2006. Production and characterization of antihypertensive angiotensin I-converting enzyme inhibitor from Pholiota adiposa. J. Microbiol. Biotechnol. 16:757-763.
14 Kim, J. H., Lee, D. H., Jeong, S. C., Chung, K. S. and Lee, J. S. 2004. Characterization of antihypertensive angiotensin I-convertong enzyme inhibitor from Saccharomyces cerevisiae. J. Microbiol. Biotechnol. 14:1318-1323.
15 Lee, D. H., Lee D. H. and Lee, J. S. 2007. Characterization of new antidementia ${\beta}-secretase$ inhibitory peptide from Saccharomyces cerevisiae. Enzyme and Microbiol Technol. 42:83-88.   DOI   ScienceOn