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http://dx.doi.org/10.4489/KJM.2006.34.2.105

The Immuno-Modulatory and Antitumor Effects of Crude Polysaccharides Extracted from Tremella fuciformis  

Oh, Yun-Hee (Department of Biology, University of Incheon)
Kim, Sang-Beom (Department of Biology, University of Incheon)
Lee, Gun-Woo (Department of Biology, University of Incheon)
Kim, Hye-Young (Department of Biology, University of Incheon)
Shim, Mi-Ja (Department of Life Science, University of Seoul)
Rho, Hyun-Su (Department of Microbiology, Gyeongsang National University)
Lee, Hyun-Sook (Department of Microbiology, Gyeongsang National University)
Lee, Min-Woong (Department of Biology, Dongguk University)
Lee, U-Youn (Department of Biology, University of Incheon)
Lee, Tae-Soo (Department of Biology, University of Incheon)
Publication Information
The Korean Journal of Mycology / v.34, no.2, 2006 , pp. 105-111 More about this Journal
Abstract
Tremella fuciformis, one of edible and medicinal mushroom belonging to Tremellaceae of Basidiomycota, has been known to have a curative effect on sarcoma 180 of mice and lowering high blood pressure of human beings. Neutral salt soluble [0.9% NaCl (Fr. NaCl)], hot water soluble (Fr. HW) and methanol soluble (Fr. MeOH) substances were extracted from Tremella fuciformis. In vitro cytotoxicity tests, Fr. HW and Fr. NaCl were not cytotoxic against cancer cell lines such as NIH3T3, Sarcoma 180, and HT-29 at the concentration of $2000{\mu}g/ml$, while Fr. MeOH was cytotoxic to NIH3T3 and Sarcoma 180. Intraperitoneal injection with Fr. NaCl showed antitumor effect with life prolongation of 53% in mice inoculated with Sarcoma 180. Fr. NaCl improved the immunopotentiation activity of B lymphocyte by increasing the alkaline phosphatase activity by $3.0{\sim}8.1$ folds, respectively. Intraperitoneal injection with Fr. NaCl increased the numbers of peritoneal exudated cells and circulating leukocytes by 7.4 folds and 1.6 folds, respectively, than in the control group. The antitumor effect of T. fuciformis against Sarcoma 180 of mice was likely due to immunopotentiation activity.
Keywords
Antitumor effect; Crude polysaccharides; Immuno-modulatory; Tremella fuciformis;
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Times Cited By KSCI : 2  (Citation Analysis)
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