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http://dx.doi.org/10.6111/JKCGCT.2017.27.5.235

Fabrication and characterization of porous hydroxyapatite scaffolds with PMMA addition using tertiary-butyl alcohol based freeze casting method  

Kim, Tae-Rim (School of Medicine, Pusan National University)
Yoon, Seog-Young (School of Materials Science Engineering, Pusan National University)
Heo, Jin-Young (S-ONE Bio Corporation)
Lee, Chi-Seung (School of Medicine, Pusan National University)
Publication Information
Journal of the Korean Crystal Growth and Crystal Technology / v.27, no.5, 2017 , pp. 235-242 More about this Journal
Abstract
In order to prepare porous scaffolds capable of pore control, PMMA powder serving as a pore-forming agent was added to HA powder to synthesize a slurry containing TBA as a solvent. And then, porous HA scaffolds where pillarshaped pore channels interconnected with each other were fabricated by freeze-casting and sintering. The crystal structure of the HA scaffolds according to the addition amount of PMMA powder was measured by XRD and the surface and inner cross section of the scaffolds were analyzed through SEM. It was found that removal of PMMA during sintering affects the internal structure of the scaffolds and the crystallinity of the HA powder. Furthermore, through evaluating the physical and mechanical properties of the scaffolds, it was confirmed that the porosity, pore size and compressive strength can be controlled by controlling the addition amount of the pore-forming agent. It was also found that the HA scaffolds produced in this study were similar in structure and properties to the natural cancellous bone. This suggests that porous HA scaffolds with PMMA can be used as an alternative to autogenous bone for tissue engineering as an artificial bone scaffold.
Keywords
Hydroxyapatite; PMMA; Scaffold; Freeze casting; Tertiary-butyl alcohol; Compressive strength; Porosity; Pore size;
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Times Cited By KSCI : 6  (Citation Analysis)
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