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http://dx.doi.org/10.6111/JKCGCT.2011.21.6.240

Intercalation behavior study of ibuprofen/clay organic-inorganic nanocomposites as drug release system  

Choi, Bong-Seok (School of Materials Science Engineering, Pusan National University)
Kim, Dong-Hyun (School of Materials Science Engineering, Pusan National University)
Kim, Tae-Wan (School of Materials Science Engineering, Pusan National University)
Jin, Heoyng-Ho (School of Materials Science Engineering, Pusan National University)
Park, Hong-Chae (School of Materials Science Engineering, Pusan National University)
Yoon, Seog-Young (School of Materials Science Engineering, Pusan National University)
Publication Information
Journal of the Korean Crystal Growth and Crystal Technology / v.21, no.6, 2011 , pp. 240-245 More about this Journal
Abstract
This research focused on the intercalation behavior of recrystallized ibuprofen into clay as a sustained release drug carrier. The intercalation behaviors of ibuprofen were determined by X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The basal spacing ($d_{001}$) of clay increased from 1.2 nm to 1.5 nm by ibuprofen molecules. The segmental motion effect of ibuprofen into the clay interlayer spacing also increased the thermal stability of the ibuprofen/clay nanocomposites. The in vitro drug release results of nanocomposites showed that ibuprofen was released from clay steadily.
Keywords
Clay; Intercalation; Ibuprofen; Nanocomposites;
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