Browse > Article
http://dx.doi.org/10.6111/JKCGCT.2011.21.3.124

Fabrication of PLA/TiO2 nanofibers using melt-electro-spinning  

Hwang, Ji-Young (Department of Advanced Materials Science and Technology, Dankook University)
Kim, Hui-Jin (Korea Institute of Industrial Technology)
Park, No-Hyung (Korea Institute of Industrial Technology)
Huh, Hoon (Korea Institute of Industrial Technology)
Park, Choon-Keun (Korea Institute of Industrial Technology)
Yoon, Jong-Won (Department of Advanced Materials Science and Technology, Dankook University)
Abstract
Electrospun webs have been widely investigated for applying to drug delivery system (DDS) because of their high specific surface area and high porosity. In this study, the composite webs of PLA (poly(lactic acid)) and $TiO_2$ were fabricated by melt-electro-spinning method for applying to drug delivery system. The morphologies of PLA/$TiO_2$, webs were observed using scanning electron microscope (SEM) and field emission transmission electron microscope (FE-TEM). The crystal structures of PLA/$TiO_2$ composite webs were confirmed by X-ray diffractometer (XRD).
Keywords
Poly(lactic acid); Titanium oxide; Nanocomposite; Melt-electro-spinning;
Citations & Related Records
연도 인용수 순위
  • Reference
1 M.E. Davis, Z.G. Chen and D.M. Shin, "Nanoparticle therapeutics: an emerging treatment modality for cancer", Nat Rev Drug Discovery. 7 (2008) 771.   DOI   ScienceOn
2 C. Chen, G. Lv, C. Pan, M. Song, C. Wu, D. Guo, X. Wang, B. Chen and Z. Gu, "Poly(lactic acid) (PLA) based nanocomposites-a novel way of drug-releasing", Biomedical Materials 2 (2007) L1.   DOI   ScienceOn
3 Y.H. Na, Y. He, X. Shuai, Y. Kikkawa, Y. Doi and Y. Inoue, "Compatibilization effect of poly(epsilon-caprolactone)- b-poly(ethylene glycol) block copolymers and phase morphology analysis in immiscible poly(lactide)/ poly(epsilon-caprolactone) blends", Biomacromolecules. 3 (2002) 1179.   DOI   ScienceOn
4 J. Lyons, C. Li and F. Ko, "Melt-electrospinning part I: processing parameters and geometric properties", Polymer. 45 (2004) 7597.   DOI   ScienceOn
5 J.K. Savaiano and T.J. Webster, "Altered responses of chondrocytes to nanophase PLGA/nanophase titania composites", Biomaterials. 25 (2004) 1205.   DOI   ScienceOn
6 J.S. Kim and D.S. Lee, "Thermal properties of electrospun polyesters", Polymer Journal 32 (2000) 616.   DOI   ScienceOn
7 Y. Ikada and H. Tsuji, "Biodegradable polyesters for medical and ecological applications", Macromol. Rapid Commun. 21 (2000) 117.   DOI   ScienceOn
8 H. Verhoogt, B.A. Ramsay and B.D. Favis, "Polymer Blends Containing Poly(3-Hydroxyalkanoate)S", Polymer. 35 (1994) 5155.   DOI   ScienceOn
9 L. Larrondo and S.J. Manley, "Electrostatic fiber spinning from polymer melts. II. Examination of the flow field in an electrically driven jet", Journal of Polymer Science Polymer Physics Edition. 19 (1981) 921.   DOI
10 L. Larrondo and S.J. Manley, "Electrostatic fiber spinning from polymer melts. III. Electrostatic deformation of a pendant drop of polymer melt", Journal of Polymer Science Polymer Physics Edition. 19 (1981) 933.   DOI
11 J. Doshi and D.H. Reneker, "Electrospinning process and application of electrospun fibers", Journal of Electrostatics. 35 (1995) 151.   DOI   ScienceOn
12 J. Lyons, Ph.D dissertation, "Melt-electrospinning of Thermoplastic Polymers: An Experimental and Theoretical Analysis", Drexel University (2004).
13 L. Larrondo and S.J. Manley, "Electrostatic fiber spinning from polymer melts. I. Experimental observations on fiber formation and properties", Journal of Polymer Science Polymer Physics Edition. 19 (1981) 909.   DOI
14 C.J. Buchko, L.C. Chen, Y. Shen and D.C. Martin, "Processing and microstructural characterization of porous biocompatible protein polymer thin films", Polymer. 40 (1999) 7397.   DOI   ScienceOn
15 Z.M. Huang, Y.Z. Zhang, M. Kotaki and S. Ramakrishna, "A review on polymer nanofibers by electrosponnong and their applications in nanocomposites", Composites Science and Technology 63 (2003) 2223.   DOI   ScienceOn
16 E.R. Kenawy, F.I. Adbel-Hay, M.H El-newehy and G.E. Wnek, "Processing of polymer nanofibers through electrospinning as drug delivery systems", Materials Chemistry and Physics. 113 (2009) 296.   DOI   ScienceOn