Browse > Article
http://dx.doi.org/10.6111/JKCGCT.2010.20.5.243

Synthesis and characterization of silicon ion substituted biphasic calcium phosphate  

Song, Chang-Weon (School of Materials Science Engineering, Pusan National University)
Kim, Tae-Wan (School of Materials Science Engineering, Pusan National University)
Kim, Dong-Hyun (School of Materials Science Engineering, Pusan National University)
Park, Hong-Chae (School of Materials Science Engineering, Pusan National University)
Yoon, Seog-Young (School of Materials Science Engineering, Pusan National University)
Publication Information
Journal of the Korean Crystal Growth and Crystal Technology / v.20, no.5, 2010 , pp. 243-248 More about this Journal
Abstract
Si-substituted biphasic calcium phosphates (Si-BCP) were prepared by co-precipitation method. X-ray diffraction and fourier transform infrared spectroscopy were used to characterize the structure of Si-BCP powders. The Si-BCP powders with various Ca/(P+Si) molar ratio were carried out on structural change of hydroxyapatite (HAp) and ${\beta}$-tricalcium phosphate ($\ss$-TCP). The in-vitro bioactivity of the Si-BCP powders was determined by immersing the powders in SBF solution, after that observing the chemical composition and morphology change by X-ray diffraction, scanning electron microscope and energy dispersive spectroscopy.
Keywords
Silicon; Biphasic calcium phosphate; Substitution; Bioactivity;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 X.W. Li, H.Y. Yasuda and Y. Umakoshi., "Bioactive ceramic composites sintered from hydroxyapatite and silica at 1200 C: preparation, microstructures and in vitro bone-like layer growth", J. Mater. Sci: Mater. Med. 17 (2006) 573.   DOI   ScienceOn
2 D.J. Baek, T.Y. Yang, Y.B. Lee, S.Y. Yoon and H.C. Park, "Fabrication of hydroxyapatite whiskers by hydrolysis of $\alpha$-TCP", J. Kor. Ceram. Soc. 40 (2003) 608.   과학기술학회마을   DOI   ScienceOn
3 E.M. Carlisle, "Silicon: a requirement in bone formation independent of vitamin D1", Calcif. Tissue. Int. 33 (1981) 27.   DOI   ScienceOn
4 I.R. Gibson, S.M. Best and W. Bonfield, "Chemical characterization of siliconsubstituted hydroxyapatite", J. Biomed. Mater. Res. 44 (1999) 422.   DOI   ScienceOn
5 Mao-Shuan Huang, Hong-Da Wu, Nai-Chia Teng, Bou- Yue Peng, Jia-Yo Wu, Wei-Jen Chang, Jen-Chang Yang, Chien-Chung Chen and Sheng-Yang Lee, "In vivo evaluation of poorly crystalline hydroxyapatite-based biphasic calcium phosphate bone substitutes for treating dental bony defects", J. Dent. Sci. 5(2) (2010) 100.   DOI   ScienceOn
6 Joel W. Reid, Loughlin Tuck, Michael Sayer, Karen Fargo and Jason A. Hendry, "Synthesis and characterization of single-phase silicon-substituted a-tricalcium phosphate", Biomaterials 27 (2006) 2916.   DOI   ScienceOn
7 I.R. Gibson, S.M. Best and W. Bonfield, "Effect of silicon substitution on the sintering and microstructure of hydroxyapatite", J. Am. Ceram. Soc. 85 (2002) 2771.
8 J.M. Burnell, E.J. Teubner and A.G. Miller, "Normal maturational changes in bone matrix, mineral, and crystal size in the rat", Calcif. Tissue. Int. 31 (1980) 13.   DOI   ScienceOn
9 S.G. Dahl, P. Allain, P.J. Marie, Y. Mauras, G. Boivin and P. Ammann, "Incorporation and distribution of strontium in bone", Bone 28 (2001) 446.   DOI   ScienceOn
10 E. Shorr and A.C. Carter, "The usefulness of strontium as an adjuvant to calcium in the remineralization of the skeleton in man", Bull. Hosp. Jt. Dis. Orthop. Inst. 13 (1952) 59.
11 W. Suchanek and M. Yoshimura, "Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants", J. Mater. Res. 13 (1998) 94.   DOI   ScienceOn
12 E.B. Nery, R.Z. LeGeros, K.L. Lynch and K. Lee, "Tissue response to biphasic calcium phosphate ceramic with different ratios of HA/beta TCP in periodontal osseous defects", Periodontol 63 (1992) 729.   DOI
13 A.E. Porter, C.M. Botelho, M.A. Lopes, J.D. Santos, S.M. Best and W. Bonfield, "Ultrastructural comparison of dissolution and apatite precipitation on hydroxyapatite and silicon-substituted hydroxyapatite in vitro and in vivo", J. Biomed. Mater. Res. A 69 (2004) 670.
14 A.M. Pietak, J.W. Reid, M.J. Stott and M. Sayer, "Silicon substitution in the calcium phosphate bioceramics", Biomaterials 28 (2007) 4023.   DOI   ScienceOn
15 A.E. Porter, N. Patel, J.N. Skepper, S.M. Best and W. Bonfield, "Comparison of in vivo dissolution processes in hydroxyapatite and silicon-substituted hydroxyapatite bioceramics", Biomaterials 24 (2003) 4609.   DOI   ScienceOn
16 Y. Ota, T. Iwashita, T. Kasuga, Y. Abe and A. Seki, "Bone formation following implantation of fibrous compounds ($\beta$-Ca(PO3)2, CaCO3(Aragonite)) into bone marrow", J. Mater. Sci. 12 (2002) 895.
17 J.H. Kim, Y.M. Park, Y.Y. Yang, S.Y. Yoon and H.C. Park, "Microstructural development in synthetic hydroxyapatite", J. Kor. Ceram. Soc. 41 (2004) 289.   과학기술학회마을   DOI   ScienceOn
18 S. Sanchez-Salcedo, F. Balas, I. Izquierdo-Barba and M. Vallet-Regi, "In vitro structural changes in porous HA/ b-TCP scaffolds in simulated body fluid", Acta Biomaterialia 5 (2009) 2738.   DOI   ScienceOn
19 G. Gasqueres, C. Bonhomme, J. Maquet, F. Babonneau, S. Hayakaw, T. Kanaya and A. Osakab, "Revisiting silicate substituted hydroxyapatite by solid state NMR", Magn. Reson. Chem. 46 (2008) 342.   DOI   ScienceOn
20 M. Vallet-Regi and D. Arcos, "Silicon substituted hydroxyapatites. A method to upgrade calcium phosphate based implants", J. Mater. Chem. 15 (2005) 1509.   DOI   ScienceOn
21 R.W. Bucholz, A. Carlton and R.E. Holmes, "Hydroxyapatite and tricalcium phosphate bone graft substitutes", Orthop. Clic. North Am. 18 (1987) 323.
22 A. Bigi, E. Foresti, R. Gregorini, A. Ripamonti, N. Roveri and J.S. Shah, "The role of magnesium on the structure of biological apatites", Calcif. Tissue. Int. 50 (1992) 439.   DOI   ScienceOn
23 Maria Vallet-Regi and Daniel Arcos, "Silicon substituted hydroxyapatites. A method to upgrade calcium phosphate based implants" J. Mater. Chem. 15 (2005) 1509.   DOI   ScienceOn
24 F. Balas, J. Perez-Pariente and M. Vallet-Regi, "In vitro bioactivity of siliconsubstituted Hydroxyapatites", J. Biomed. Mater. Res. A 66 (2003) 364.
25 L. Medvecky, R. Sulajterova, L. Parilak, J. Trpcevska, J. Durisin and S.M. Barinov, "Influence of manganese on stability and particle growth of hydroxyapatite in simulated body fluid? Colloids Surf A 281 (2006) 221.   DOI   ScienceOn
26 H. Rico, N. Gomez-Raso, M. Revilla, E.R. Hernandez, C. Seco and E. Paez, "Effects on bone loss of manganese alone or with copper supplement in ovariectomized rats: a morphometric and densitometric study", Eur. J. Obstet. Gynecol. Reprod. Biol. 90 (2009) 97.
27 N. Patel, S.M. Best and W. Bonfield, "Characterization of hydroxyapatite and substituted-hydroxyapatites for bone grafting", J. Aust. Ceram. Soc. 41 (2005) 1.
28 R.Z. LeGeros, S. Lin, R. Rohanizadeh, D. Mijares and J.P. LeGeros, "Biphasic ca1cium phosphate bioceramics: preparation, properties and applications", J. Mater. Sci. Mater. Med. 14 (2003) 201.   DOI   ScienceOn
29 A.S. Prasad, "Zinc: an overview", Nutrition 11 (1995) 93.