Browse > Article
http://dx.doi.org/10.6111/JKCGCT.2010.20.2.093

Determination of stoichiometric Ca/P ratio in biphasic calcium phosphates using X-ray diffraction analysis  

Song, Yong-Keun (School of Materials Science Engineering, Pusan National University)
Kim, Dong-Hyun (School of Materials Science Engineering, Pusan National University)
Kim, Tae-Wan (School of Materials Science Engineering, Pusan National University)
Kim, Yang-Do (School of Materials Science Engineering, Pusan National University)
Park, Hong-Chae (School of Materials Science Engineering, Pusan National University)
Yoon, Seog-Young (School of Materials Science Engineering, Pusan National University)
Publication Information
Journal of the Korean Crystal Growth and Crystal Technology / v.20, no.2, 2010 , pp. 93-100 More about this Journal
Abstract
The calcium to phosphate ratio (Ca/P) in biphasic calcium phosphates powders using X-ray diffraction analysis (XRD) was characterized. The BCP powders with various stoichiometric Ca/P molar ratio were synthesized with coprecipitation process and calcination. Compositions of the powders with Ca/P molar ratio between 1.5 and 1.67 were subjected to starting Ca/P molar ratio, pH = 10, and thermal treatment up to $900^{\circ}C$. The structural, morphological and chemical characterizations for BCP powders with stoichiometric Ca/P ratio were carried out with scanning electron microscope (SEM) and inductively coupled plasma atomic emission spectroscopy (ICP-AES) and a phase quantification was investigated by XRD. The solubility of HAp, $\beta$-TCP, and BCP powders was tested in the phosphate buffer solution (PBS) at $36.5^{\circ}C$ and pH = 7.4.
Keywords
Biphasic calcium phosphate; X-Ray diffraction analysis; Ca/P ratio;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 R.Z. LeGeros, S. Lin, R. Rohanizadeh, D. Mijares and J.P. LeGeros, "Biphasic Calcium phosphate bioceram-ics:preparation, properties and applications", J. Mater. Sic. 14 (2003) 201.
2 R.Z. LeGeros, "Calcium phosphates in oral biology and medicine (Monograph in Oral Science) Karger 15 (1991).
3 S.V. Dorozhkin, "Solid-state transformation of a nonstoichiomet ric calcium deficient apatite into the biphasic calcium phosphate", Key Eng. 192-195 (2001) 155-158.   DOI
4 M. Benahmed, J.M. Bouler, D. Heymann, O. Gan and G. Daculsi, "Biodegradation of synthetic biphasic calcium phosphate by human monocytes in vitro", Biomaterials 17 (1996) 2173.   DOI   ScienceOn
5 R. Xin, Y. Leng, J. Chen and Q. Zhang, "A comparative study of calcium phosphate formation on bioceramics in vitro and in vivo", Biomaterials 26 (2005) 6477.   DOI   ScienceOn
6 R.Z. LeGeros, "Apatites in biological system", Prog. Crystal Growth Charact. 4 (1981).
7 S.H. Kwon, Y.K. Jun, S.H. Hong and H.E. Kim, "Synthesis and dissolution behavior of $\beta$-TCP and HA/$\beta$-TCP composite powders", J. Eur. Ceram. Soc. 23 (2003) 1039.   DOI   ScienceOn
8 C.K. Hsu, "The preparation of biphasic porous calcium phosphate by the mixture of $Ca(H_{2}PO_{4})_{2}H_{2}O$and $CaCO_{3}$", Mater. Chem. & Phys. 9470 (2002) 1.
9 Y. Pand, J.A. Huang and C.Y. Shao, "Preparation of $\beta$-TCP with high thermal stability by solid reaction route", J. Mater. Sci. 38 (2003) 1049.   DOI   ScienceOn
10 N. Kivrak and A.C. Tas, "Synthesis of calcium hydroxyapatite-tri calcium phosphate (HA-TCP) composite bioceramic powders and their sintering behavior", J. Am. Ceram. Soc. 81 (1998) 2245.
11 W. Suchanek and M. Yoshimura, "Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants", J. Mater. Res. 13 (1998) 94.   DOI   ScienceOn
12 I. Manjubala and M. Sivakumar, "In-situ synthesis of biphasic calcium phosphate ceramics using microwave irradiation", Mater. Chem. & Phys. 71 (2001) 272.   DOI   ScienceOn
13 Y. Ota, T. Iwashita, T. Kasuga, Y. Abe and A. Seki, "Bone formation following implantation of fibrous compounds $(\beta-Ca(PO_{3})_{2}, CaCO_{3}(Aragonite))$ into bone marrow", J. Mater. Sci. 12 (2002) 895.
14 J.H. Kim, Y.M. Park, Y.Y. Yang, S.Y. Yoon and H.C. Park, "Microstructural develpment in synthetic hydroxyapatite", J. Kor. Ceram. Soc. 41 (2004) 289.   과학기술학회마을   DOI   ScienceOn
15 D.J. Baek, T.Y. Yang, Y.B. Lee, S.Y. Yoon and H.C. Park, "Fabrication of hydroxyapatite whiskers by hydrolysis of $\alpha$-TCP", J. Kor. Ceram. Soc. 40 (2003) 608.   과학기술학회마을   DOI   ScienceOn
16 S.-H. Kwon, Y.-K. Jun, S.-H. Hong and H.-E. Kim, "Synthesis and dissolution behavior of $\beta$-TCP and HA/$\beta$-TCP composite powders", J. Euro. Ceram. Soc. 23 (2003) 1039.   DOI   ScienceOn
17 K.-B. Park, J.-W. Park, H.-U. Ahn, D.-J. Yang, S.-K. Choi, I.-S. Jang, S.-I. Yeo and J.-Y. Suh, "Comparative study on the physicochemical properties and cytocom patibility of microporous biphasic calcium phosphate ceramics as a bone graft substitute", Journal of Periodontal & Implant Science 36 (2006) 797.
18 R.W. Bucholz, A. Carlton and R.E. Holmes, "Hydroxyapatite and tricalcium phosphate bone graft substitutes", Orthop. Clic. North Am. 18 (1987) 323.