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http://dx.doi.org/10.3740/MRSK.2021.31.6.367

Gentamicin/CTMA/Montmorillonite as Slow-Released Antibacterial Agent  

Fatimah, Is (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Islam Indonesia, Kampus Terpadu UII)
Hidayat, Habibi (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Islam Indonesia, Kampus Terpadu UII)
Purwiandono, Gani (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Islam Indonesia, Kampus Terpadu UII)
Husein, Saddam (Laboratory of Materials for Energy and Environemnt, Department of Chemistry, Universitas Islam Indonesia, Kampus Terpadu UII)
Oh, Won-Chun (Department of Advanced Materials Science and Engineering, Hanseo University)
Publication Information
Korean Journal of Materials Research / v.31, no.6, 2021 , pp. 367-374 More about this Journal
Abstract
This paper presents the characteristics of gentamicin-loaded into cetyl trimethyl ammonium intercalated montmorillonite (GtM/CTMA/Mt) as a hybrid composite for a slow-released antibacterial delivery systems. The work describes the successful immobilization of gentamicin into the interlayers of surfactant-modified montmorillonite. Physicochemical characterization of the material is carried out by means of X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Fourier transform infrared spectroscopy. The kinetics of the gentamicin release is investigated by in vitro study and analyzed based on UV-Vis spectrometry. In addition, antibacterial study is performed towards Klebsiella pneumoniae Staphylococcus aureus, Escherichia coli, and Streptococcus pyogenes. The results show that the gentamicin loading into CTMA/Mt increases the effectiveness of the antibacterial activity, as shown by the higher inhibition zone for all tested bacteria, compared to gentamicin as a positive control. The kinetics study suggests that the gentamicin release obeys the modified Korsmeyer-Peppas model. The physicochemical study and activity test demonstrate the feasibility of the GtM/CTMA/Mt for practical applications.
Keywords
antibacterial agent; slow-released drug; intercalated clay; organoclay;
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1 S. Tang, B. Tian, Q. F. Ke, Z. A. Zhu and Y. P. Guo, RSC Adv., 40, 41500 (2014).
2 Y. Y. Loo, Y. Rukayadi, M. A. R. Nor-Khaizura, C. H. Kuan, B. W. Chieng, M. Nishibuchi and S. Radu, Front. Microbiol., 9, 1 (2018).   DOI
3 U. Posadowska and M. Brzychczy-Wloch, Acta Bioeng. Biomech., 17, 41 (2015).
4 M. Stigter, J. Bezemer, K. D. Groot and P. Layrolle, J. Control. Release, 99, 127 (2004).   DOI
5 D. Wojcik-Pastuszka, J. Krzak, B. Macikowski, R. Berkowski and B. Osinski, Materials (Basel)., 12, 1202 (2019).   DOI
6 I. Y. Wu, S. Bala, N. Skalko-Basnet and M. P. D. Cagno, Eur. J. Pharm. Sci., 138, 105026 (2019).   DOI
7 G. Arora, K. Malik and I. Singh, Polim. Med., 41, 23 (2011).
8 R. Gouda, H. Baishya and Z. Qing, J. Dev. Drugs., 06, 1000171 (2017).
9 G. Franci, A. Falanga, S. Galdiero, L. Palomba, M. Rai, G. Morelliiano and M. Galdiero, Molecules, 20, 8856 (2015).   DOI
10 X. Chen, C. Xu and H. He, Biophys. Res. Commun., 516, 1085 (2019).   DOI
11 D. Garibo, H. A. Borbon-Nunez, J. N. D. D. Leon, E. G. Mendoza, I. Estrada, Y. Toledano-Magana, H. Tiznado, M. Ovalle-Marroquin, A. G. Soto-Ramos, A. Blanco, J. A. Rodriguez, O. A. Romo, L. A. Chavez-Almazan and A. Susarrey-Arce, Sci. Rep., 10, 12805 (2020).   DOI
12 W. Luo, Z. Geng, Z. Li, S. Wu, Z. Cui, S. Zhu, Y. Liang and X. Yang, Int. J. Nanomedicine, 13, 7491 (2018).   DOI
13 Y. He, Z. Wu, L. Tu, Y. Han, G. Zhang and C. Li, Appl. Clay Sci., 109-110, 68 (2015).   DOI
14 M. Karthikeyan, M. K. Deepa, E. Bassim, C. S. Rahna and K. R. S. Raj, J. Pharm. Innov., Research Article (2020).
15 L. Zhang, J. Chen, W. Yu, Q. Zhao and J. Liu, J. Nanomater., 2018, 6190251 (2018).
16 X. Yuan, J. Zhang, R. Zhang, J. Liu, W. Wang and H. Hou, Materials (Basel)., 12, 4148 (2019).   DOI
17 M. Honarmand, M. Golmohammadi and A. Naeimi, Mater. Chem. Phys., 241, 122416 (2020).   DOI
18 I. Fatimah, D. Rubiyanto, I. Sahroni, R. S. Putra, R. Nurillahi and J. Nugraha, Appl. Clay Sci., 193, 105671 (2020).   DOI
19 I. Fatimah and T. Huda, Appl. Clay Sci., 74, 115 (2013).   DOI
20 R. Batul, M. Bhave, P. J. Mahon and A. Yu, Molecules, 25, 1 (2020).
21 A. Bayoumi, M. T. Sarg, T. Y. A. Fahmy, N. F. Mohamed and W. K. El-Zawawy, Arab. J. Chem., 13, 8920 (2020).   DOI
22 P. Gao, X. Nie, M. Zou, Y. Shi and G. Cheng, J. Antibiot., 64, 625 (2011).   DOI
23 A. Rapacz-Kmita, E. Stodolak-Zych, M. Dudek, M. Gajek, M. Ziabka, J. Therm. Anal. Calorim., 127, 871 (2017).   DOI
24 Y. Liu, P. Ji, H. Lv, Y. Qin and L. Deng, Int. J. Biol. Macromol., 98, 550 (2017).   DOI
25 G. Lv, C. W. Pearce, A. Gleason, L. Liao, M. P. MacWilliams and Z. Li, J. Asian Earth Sci., 77, 281 (2013).   DOI
26 H. Bujdakova, V. Bujdakova, H. Majekova-Koscova, B. Gaalova, V. Bizovska, P. Bohac and J. Bujdak, Appl. Clay Sci., 158, 21 (2018).   DOI
27 M. Anggraini, A. Kurniawan, L. K. Ong, M. A. Martin, J. C. Liu, F. E. Soetaredjo, N. Indraswati and S. Ismadji, RSC Adv., 4, 16298 (2014).   DOI
28 T. Saitoh and T. Shibayama, J. Hazard. Mater., 317, 677 (2016).   DOI
29 P. Herrera, R. C. Burghardt and T. D. Phillips, Vet. Microbiol., 74, 259 (2000).   DOI
30 M. R. Virto, P. Frutos, S. Torrado and G. Frutos, Biomaterials, 24, 79 (2003).   DOI
31 S. Perni, K. Martini-Gilching and P. Prokopovich, Colloids Surfaces A Physicochem. Eng. Asp., 541, 212 (2018).   DOI
32 L. Zarate-Reyes, C. Lopez-Pacheco, A. Nieto-Camacho, E. Palacios, V. Gomez-Vidales, S. Kaufhold, K. Ufer, E. G. Zepeda and J. Cervini-Silva, J. Hazard. Mater., 342, 625 (2018).   DOI
33 M. Stevanovic, M. Dosic, A. Jankovic, V. Kojic, M. Vukasinovic-Sekulic, J. Stojanovic, J. Odovic, M. C. Sakac, K. Y. Rhee and V. Miskovic-Stankovic, ACS Biomater. Sci. Eng., 4, 3994 (2018).   DOI
34 D. A. Mosselhy, Y. Ge, M. Gasik, K. Nordstrom, O. Natri and S. P. Hannula, Materials (Basel)., 9, 1 (2016).   DOI
35 A. S. Maryan, M. Montazer, A. Rashidi and M. K. Rahimi, Asian J. Chem., 25, 2889 (2013).   DOI