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http://dx.doi.org/10.17703/JCCT.2020.6.2.543

The Effects of Anti-Inflammatory Activities and Active Fractions Analysis of Ethanol Extract from Red Rose Petals  

Kim, Hyun Kyoung (Dept. of Food Science and Engineering, Seowon Univ)
Publication Information
The Journal of the Convergence on Culture Technology / v.6, no.2, 2020 , pp. 543-551 More about this Journal
Abstract
Red rose petals are usually disposed but they are an abundant source of phenolics and traditionally used as food supplement and as herbal medicine. Of the Various phenolics, they are known to have anticancer, antioxidant, and anti-inflammatory properties. In this study, we investigated the anti-inflammatory effects of red rose ethanolic extracts(GRP) on lipopolysaccharide (LPS)-activated RAW 264.7 cells. The results demonstrated that pretreatment of GRP(500㎍/mL) significantly reduced NO production by suppressing iNOS protein expression in LPS-stimulated cells. Anti-inflammatory effects byred rose petal were observed in the following. Red rose petal inhibited the translocation of NF-κB from the cytosol to the nucleus via the suppression of IκB-α phosphorylation and also inhibited LPS-stimulated NF-κB transcriptional activity. These findings suggest that red rose petal exert anti-inflammatory actions and help to elucidate the mechanisms underlying the potential therapeutic values of red rose petal. Therefore, red rose petal could be regarded as a potential source of natural anti-inflammatory agents.
Keywords
Red Rose Petal; Anti-Inflammation; Nitric Oxide; Active Fractions; Cell Viability;
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Times Cited By KSCI : 5  (Citation Analysis)
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