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http://dx.doi.org/10.4283/JKMS.2006.16.6.293

Characteristics of Lecithin-adsorbed Magnetic Nanoparticle and Biocompatibility of Its Fluid  

Park, Sang-Im (Dept. of Materials Science and Eng., Chungnam Nat'l University)
Kim, Chong-Oh (Dept. of Materials Science and Eng., Chungnam Nat'l University)
Kim, Jong-Hee (Research Center for Advanced Magnetic Materials, Chungnam Nat'l University)
Kim, Seong-Min (Dept. of Nuclear Medicine, Chungnam Nat'l University Hospital)
Kim, Keun-Ho (Dept. of Nuclear Medicine, Chungnam Nat'l University Hospital)
Publication Information
Journal of the Korean Magnetics Society / v.16, no.6, 2006 , pp. 293-299 More about this Journal
Abstract
Magnetic nanoparticles were prepared by thermal decomposition and adsorbed with lecithin by applying ultrasonic. The size and saturation magnetization of magnetic nanoparticles were observed with different lecithin concentration, and the maximum tolerated dose (HTD) and toxicity of magnetic fluid was investigated through a biological test. The thickness of lecithin-adsorption layer increased non-linearly with increasing amounts of added lecithin, and the desirable adsorption amount was observed in the lecithin concentration of 20%(w/v). The dispersibility and magnetic properties of lecithin-adsorbed magnetic nanoparticles were most excellent when the ultrasonic exposure time was 1.5h. Also, the maximum tolerated concentration with best cell viability was $32{\mu}g/ml$ in vitro test, and lecithin-adsorbed magnetic fluids improved the biocompatibility by 1.2 times compared with bare magnetite fluids in vivo.
Keywords
magnetic nanoparticle; magnetic fluid; dispersibility; lecithin adsorption; biological test; toxicity;
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