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http://dx.doi.org/10.4046/trd.2019.0037

Risk Factor and Mortality in Patients with Pulmonary Embolism Combined with Infectious Disease  

Lee, Gi Dong (Department of Internal Medicine, Saint Carollo Hospital)
Ju, Sunmi (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine)
Kim, Ju-Young (Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine)
Kim, Tae Hoon (Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine)
Yoo, Jung-Wan (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine)
Lee, Seung Jun (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine)
Cho, Yu Ji (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine)
Jeong, Yi Yeong (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine)
Jeon, Kyung Nyeo (Department of Diagnostic Radiology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine)
Lee, Jong Deog (Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine)
Kim, Ho Cheol (Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.83, no.2, 2020 , pp. 157-166 More about this Journal
Abstract
Background: Infectious conditions may increase the risk of venous thromboembolism. The purpose of this study was to evaluate the risk factor for combined infectious disease and its influence on mortality in patients with pulmonary embolism (PE). Methods: Patients with PE diagnosed based on spiral computed tomography findings of the chest were retrospectively analyzed. They were classified into two groups: patients who developed PE in the setting of infectious disease or those with PE without infection based on review of their medical charts. Results: Of 258 patients with PE, 67 (25.9%) were considered as having PE combined with infectious disease. The sites of infections were the respiratory tract in 52 patients (77.6%), genitourinary tract in three patients (4.5%), and hepatobiliary tract in three patients (4.5%). Underlying lung disease (odds ratio [OR], 3.69; 95% confidence interval [CI], 1.926-7.081; p<0.001), bed-ridden state (OR, 2.84; 95% CI, 1.390-5.811; p=0.004), and malignant disease (OR, 1.867; 95% CI, 1.017-3.425; p=0.044) were associated with combined infectious disease in patients with PE. In-hospital mortality was higher in patients with PE combined with infectious disease than in those with PE without infection (24.6% vs. 11.0%, p=0.006). In the multivariate analysis, combined infectious disease (OR, 4.189; 95% CI, 1.692-10.372; p=0.002) were associated with non-survivors in patients with PE. Conclusion: A substantial portion of patients with PE has concomitant infectious disease and it may contribute a mortality in patients with PE.
Keywords
Pulmonary Embolism; Infectious Disease; Mortality;
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