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http://dx.doi.org/10.4046/trd.2014.77.6.258

Bilateral Ovarian Metastases from ALK Rearranged Non-Small Cell Lung Cancer  

Lee, Kyung Ann (Department of Internal Medicine, Konkuk University School of Medicine)
Lee, Jong Sik (Department of Internal Medicine, Konkuk University School of Medicine)
Min, Jae Ki (Department of Internal Medicine, Konkuk University School of Medicine)
Kim, Hee Joung (Department of Internal Medicine, Konkuk University School of Medicine)
Kim, Wan Seop (Department of Pathology, Konkuk University School of Medicine)
Lee, Kye Young (Department of Internal Medicine, Konkuk University School of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.77, no.6, 2014 , pp. 258-261 More about this Journal
Abstract
Anaplastic lymphoma kinase (ALK) rearrangement, is a kind of driver mutation, accounts for 3%-5% of non-small cell lung cancer (NSCLC). NSCLC patients harboring ALK fusion genes have distinct clinical features and good response to ALK inhibitors. Metastasis from lung cancer to the ovary has rarely been known. We report a case of a 54-year-old woman with bilateral ovarian metastases from ALK rearranged NSCLC. She underwent bilateral salpingo-oophorectomy for ovary masses, which were progressed after cytotoxic chemotherapy although primary lung mass was decreased. Histopathological examination of the ovary tumor showed characteristic adenocarcinoma patterns of the lung and ALK rearrangement.
Keywords
Anaplastic Lymphoma Kinase; Carcinoma; Non-Small-Cell Lung; Neoplasm Metastasis; Ovary;
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