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http://dx.doi.org/10.4046/trd.2014.76.1.30

The First Korean Case of Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium abscessus Subspecies bolletii in a Patient with Bronchiectasis  

Jeong, Byeong-Ho (Division of Pulmonary and Critical Care Medicine, Department of Medicine)
Kim, Su-Young (Division of Pulmonary and Critical Care Medicine, Department of Medicine)
Jeon, Kyeongman (Division of Pulmonary and Critical Care Medicine, Department of Medicine)
Huh, Hee Jae (Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Ki, Chang-Seok (Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Lee, Nam Yong (Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Shin, Sung Jae (Department of Microbiology, Yonsei University College of Medicine)
Koh, Won-Jung (Division of Pulmonary and Critical Care Medicine, Department of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.76, no.1, 2014 , pp. 30-33 More about this Journal
Abstract
We report the first Korean case of lung diseases caused by Mycobacterium abscessus subsp. bolletii in a previously healthy male, except for a previous history of pulmonary tuberculosis and bronchiectasis. All serial isolates are identified as M. abscessus subsp. bolletii by multi-locus sequence analysis based on the hsp65, rpoB, and 16S rRNA fragments. At the genetic level, the isolate has the erm(41) gene with a T28 sequevar, associated with clarithromycin resistance, and no rrl mutation. The isolate is resistant to clarithromycin. Although the symptoms and radiographic findings have improved after combination of antibiotics, the follow-up sputum cultures are persistently positive.
Keywords
Bronchiectasis; Mycobacterium Infections; Nontuberculous; Nontuberculous Mycobacteria; Sequence Analysis; DNA;
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