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http://dx.doi.org/10.4046/trd.2011.71.1.24

The Association of Obesity, Airway Hyperresponsiveness and Atopy in Chronic Cough Patients: Results of a Two-Center Study  

Park, So-Yong (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Hallym University College of Medicine)
Park, Jong-Won (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Hallym University College of Medicine)
Oh, Yeon-Mok (Department of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Rhee, Yang-Keun (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine,Chonbuk National University Medical School)
Lee, Young-Mok (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Soonchunhyang University College of Medicine)
Park, Yong-Bum (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Hallym University College of Medicine)
Lim, Seong-Yong (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.71, no.1, 2011 , pp. 24-29 More about this Journal
Abstract
Background: The rising prevalence of asthma worldwide may be associated with the rising prevalence of obesity in developed nations. Although several studies have suggested a relationship between asthma and obesity, controversy still remains. The aim of this study was to examine the relationship between obesity and asthmatic factors such as atopy, eosinophilia, serum total Ig E and bronchial hyperresponsiveness in chronic cough patients. Methods: This study was a retrospective, observational study in two centers done between January 2007 and June 2008. The subjects included individuals who had a chronic cough. We examined body mass index (BMI) to measure obesity and pulmonary function. We did a metacholine provocation test for airway hyperresponsiveness (AHR), a skin prick test for atopy, and tests for blood eosinophils and serum IgE. Results: A total of 1022 subjects were included. Airway hyperresponsiveness was not related with obesity (p=0.06), and atopy incidence was significant higher in non obese patients (p=0.00). There was no significant difference in serum IgE and blood eosinophil counts between obese and non obese patients. Forced expiratory volue in one second ($FEV_1$)/forced vital capacity (FVC) was significantly reduced in obese patients (p=0.03), but FEV1 and FVC were no significant difference between obese and non obese patients. Conclusion: There is no relationship between obesity and bronchial hyperresponsiveness. The nonobese group appears to have more atopy. The relationship between obesity and bronchial hyperresponsiveness and atopy need further investigation.
Keywords
Obesity; Bronchial Hyperresponsiveness; Dermatitis, Atopic;
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1 Shore SA. Obesity and asthma: possible mechanisms. J Allergy Clin Immunol 2008;121:1087-93.   DOI   ScienceOn
2 Camargo CA Jr, Weiss ST, Zhang S, Willett WC, Speizer FE. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med 1999;159:2582-8.   DOI   ScienceOn
3 Lugogo NL, Kraft M, Dixon AE. Does obesity produce a distinct asthma phenotype? J Appl Physiol 2010;108:729-34.   DOI   ScienceOn
4 Ronmark E, Andersson C, Nystrom L, Forsberg B, Jarvholm B, Lundback B. Obesity increases the risk of incident asthma among adults. Eur Respir J 2005;25:282-8.   DOI   ScienceOn
5 Pearce N, Ait-Khaled N, Beasley R, Mallol J, Keil U, Mitchell E, et al. Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2007;62:758-66.   DOI   ScienceOn
6 Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 2007;175:661-6.   DOI   ScienceOn
7 Sin DD, Sutherland ER. Obesity and the lung: 4. Obesity and asthma. Thorax 2008;63:1018-23.   DOI   ScienceOn
8 Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008;31:143-78.   DOI   ScienceOn
9 Gershon AS, Guan J, Wang C, To T. Trends in asthma prevalence and incidence in Ontario, Canada, 1996∼2005: a population study. Am J Epidemiol 2010;172:728-36.   DOI   ScienceOn
10 Gibson PG, McDonald VM, Marks GB. Asthma in older adults. Lancet 2010;376:803-13.   DOI   ScienceOn
11 Sutherland TJ, Cowan JO, Young S, Goulding A, Grant AM, Williamson A, et al. The association between obesity and asthma: interactions between systemic and airway inflammation. Am J Respir Crit Care Med 2008;178:469-75.   DOI   ScienceOn
12 Kasasbeh A, Kasasbeh E, Krishnaswamy G. Potential mechanisms connecting asthma, esophageal reflux, and obesity/sleep apnea complex--a hypothetical review. Sleep Med Rev 2007;11:47-58.   DOI   ScienceOn
13 Xu H, Uysal KT, Becherer JD, Arner P, Hotamisligil GS. Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity. Diabetes 2002;51:1876-83.   DOI   ScienceOn
14 Jacobson BC, Somers SC, Fuchs CS, Kelly CP, Camargo CA Jr. Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med 2006;354:2340-8.   DOI   ScienceOn
15 Young T, Shahar E, Nieto FJ, Redline S, Newman AB, Gottlieb DJ, et al. Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med 2002;162:893-900.   DOI   ScienceOn
16 Kim SS, Choi SH, Park MJ, Kim YS, Yim JY, Lim SH, et al. Effects of obesity and smoking on bronchial hyperresponsiveness in Korean adults. Korean J Asthma Allergy Clin Immunol 2005;25:217-22.
17 Zhong NS, Chen RC, Yang MO, Wu ZY, Zheng JP, Li YF. Is asymptomatic bronchial hyperresponsiveness an indication of potential asthma? A two-year follow-up of young students with bronchial hyperresponsiveness. Chest 1992;102:1104-9.   DOI   ScienceOn
18 Cockcroft DW, Berscheid BA, Murdock KY. Unimodal distribution of bronchial responsiveness to inhaled histamine in a random human population. Chest 1983;83:751-4.   DOI   ScienceOn
19 Beuther DA. Recent insight into obesity and asthma. Curr Opin Pulm Med 2010;16:64-70.   DOI   ScienceOn
20 Schachter LM, Salome CM, Peat JK, Woolcock AJ. Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness. Thorax 2001;56:4-8.   DOI   ScienceOn
21 Bai J, Peat JK, Berry G, Marks GB, Woolcock AJ. Questionnaire items that predict asthma and other respiratory conditions in adults. Chest 1998;114:1343-8.   DOI   ScienceOn
22 Dixon AE, Holguin F, Sood A, Salome CM, Pratley RE, Beuther DA, et al. An official American Thoracic Society Workshop report: obesity and asthma. Proc Am Thorac Soc 2010;7:325-35.   DOI   ScienceOn
23 Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999∼2008. JAMA 2010;303:235-41.   DOI   ScienceOn
24 Jarvis D, Chinn S, Potts J, Burney P; European Community Respiratory Health Survey. Association of body mass index with respiratory symptoms and atopy: results from the European Community Respiratory Health Survey. Clin Exp Allergy 2002;32:831-7.   DOI   ScienceOn
25 Chinn S, Jarvis D, Burney P; European Community Respiratory Health Survey. Relation of bronchial responsiveness to body mass index in the ECRHS. European Community Respiratory Health Survey. Thorax 2002;57:1028-33.   DOI   ScienceOn
26 Stenius-Aarniala B, Poussa T, Kvarnstrom J, Gronlund EL, Ylikahri M, Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ 2000;320:827-32.   DOI   ScienceOn
27 Korea Center for Disease Control and Prevention. National health & nutrition examination survey (KNHANES 4). Nutrition survey. Seoul: Ministry for Health, Welfare and Family Affairs; 2007.
28 Fredberg JJ, Inouye D, Miller B, Nathan M, Jafari S, Raboudi SH, et al. Airway smooth muscle, tidal stretches, and dynamically determined contractile states. Am J Respir Crit Care Med 1997;156:1752-9.   DOI   ScienceOn
29 Litonjua AA, Sparrow D, Celedon JC, DeMolles D, Weiss ST. Association of body mass index with the development of methacholine airway hyperresponsiveness in men: the Normative Aging Study. Thorax 2002;57:581-5.   DOI   ScienceOn
30 Sharp JT, Henry JP, Sweany SK, Meadows WR, Pietras RJ. The total work of breathing in normal and obese men. J Clin Invest 1964;43:728-39.   DOI
31 Raboudi SH, Miller B, Butler JP, Shore SA, Fredberg JJ. Dynamically determined contractile states of airway smooth muscle. Am J Respir Crit Care Med 1998;158:S176-8.   DOI   ScienceOn
32 Hoene M, Weigert C. The role of interleukin-6 in insulin resistance, body fat distribution and energy balance. Obes Rev 2008;9:20-9.