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http://dx.doi.org/10.4046/trd.2011.70.3.218

Effects of Curcumin and Genistein on Phorbol Ester or Tumor Necrosis Factor-${\alpha}$-Induced Mucin Production from Human Airway Epithelial Cells  

Lee, Su-Yel (Department of Pharmacology, Chungnam National University College of Medicine)
Lee, Hyun-Jae (Department of Pharmacology, Chungnam National University College of Medicine)
Lee, Jae-Woo (LG Life Science)
Jeon, Byeong-Kyou (Department of Radiologic Technology, Daegu Health College)
Kim, Ju-Ock (Pulmonology Section, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University College of Medicine)
Lee, Choong-Jae (Department of Pharmacology, Chungnam National University College of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.70, no.3, 2011 , pp. 218-223 More about this Journal
Abstract
Background: We investigated whether curcumin and genistein affect the MUC5AC mucin production from human airway epithelial cells that is induced by phorbol 12-myristate 13-acetate (PMA) or tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$). Methods: Confluent NCI-H292 cells were pretreated with each agent for 30 min and then stimulated with PMA or TNF-${\alpha}$ for 24 hours. MUC5AC mucin production was measured by an ELISA. Results: (1) Curcumin dose-dependently inhibited the production of MUC5AC mucin that was induced by PMA or TNF-${\alpha}$; (2) Genistein inhibited PMA-induced MUC5AC mucin production. However, it did not decrease TNF-${\alpha}$-induced MUC5AC mucin production. Conclusion: These results suggest that curcumin and genistein inhibit the production of airway mucin induced by PMA.
Keywords
Mucin 5AC; Curcumin; Genistein;
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