Browse > Article
http://dx.doi.org/10.4046/trd.2010.69.6.426

Infection Rate of Chlamydia pneumoniae in Patients with Chronic Cough  

Chun, Seung-Yeon (Department of Internal Medicine, Hallym University College of Medicine)
Park, Kwon-Oh (Department of Internal Medicine, Hallym University College of Medicine)
Park, Yong-Bum (Department of Internal Medicine, Hallym University College of Medicine)
Choi, Jeong-Hee (Department of Internal Medicine, Hallym University College of Medicine)
Lee, Jae-Young (Department of Internal Medicine, Hallym University College of Medicine)
Mo, Eun-Kyung (Department of Internal Medicine, Hallym University College of Medicine)
Park, Sung-Hoon (Department of Internal Medicine, Hallym University College of Medicine)
Kim, Cheol-Hong (Department of Internal Medicine, Hallym University College of Medicine)
Lee, Chang-Youl (Department of Internal Medicine, Hallym University College of Medicine)
Hwang, Yong-Il (Department of Internal Medicine, Hallym University College of Medicine)
Jang, Seung-Hun (Department of Internal Medicine, Hallym University College of Medicine)
Shin, Tae-Rim (Department of Internal Medicine, Hallym University College of Medicine)
Park, Sang-Myeon (Department of Internal Medicine, Hallym University College of Medicine)
Kim, Dong-Gyu (Department of Internal Medicine, Hallym University College of Medicine)
Lee, Myung-Goo (Department of Internal Medicine, Hallym University College of Medicine)
Hyun, In-Gyu (Department of Internal Medicine, Hallym University College of Medicine)
Jung, Ki-Suck (Department of Internal Medicine, Hallym University College of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.69, no.6, 2010 , pp. 426-433 More about this Journal
Abstract
Background: Persistent cough has recently been found to be associated with Chlamydia pneumoniae infection. We aimed to investigate the infection rate of C. pneumonia in adult patients with chronic cough. Methods: We recruited 68 patients with persistent cough lasting in excess of 3 weeks, who visited Kangdong Sacred Heart Hospital from January 2005 to August 2005. On the first visit, chest and paranasal sinuses radiography, skin prick test of common allergens, and induced sputum samples for C. pneumoniae were performed in all of patients. Further evaluation for diagnosis included a methacholine provocation test and eosinophil counts in induced sputum. Results: The most common cause of chronic cough was upper airway cough syndrome (UACS) (26.5%), followed by eosinophilic bronchitis (20.6%) and cough variant asthma (16.2%). Idiopathic chronic cough was the cause in 33.8% of patients. The mean duration of cough was 11.7 months. C. pneumoniae was isolated by polymerase chain reaction (PCR) from one patient who had upper respiratory air way syndrome. Conclusion: Chlamydia pneumoniae appears to have a minor role as a cause of chronic cough in patients.
Keywords
Cough; Polymerase Chain Reaction; Chlamydia Infections;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 Hyman CL, Roblin PM, Gaydos CA, Quinn TC, Schachter J, Hammerschlag MR. Prevalence of asymptomatic nasopharyngeal carriage of Chlamydia pneumoniae in subjectively healthy adults: assessment by polymerase chain reaction-enzyme immunoassay and culture. Clin Infect Dis 1995;20:1174-8.   DOI   ScienceOn
2 Miyashita N, Fukano H, Yoshida K, Niki Y, Matsushima T. Chlamydia pneumoniae infection in adult patients with persistent cough. J Med Microbiol 2003;52:265-9.   DOI   ScienceOn
3 Kim WJ, Lee HY, Lee ME, Lee SJ. Serology of Chlamydia pneumoniae in patients with chronic cough. Respirology 2006;11:805-8.   DOI   ScienceOn
4 Smieja M, Mahony JB, Goldsmith CH, Chong S, Petrich A, Chernesky M. Replicate PCR testing and probit analysis for detection and quantitation of Chlamydia pneumoniae in clinical specimens. J Clin Microbiol 2001; 39:1796-801.   DOI   ScienceOn
5 Lee HS, Chun BY, Jin SH, Lee WK. Infection rate of Chlamydia pneumoniae by serological antibody test between patients with respiratory symptoms and control group. Korean J Clin Microbiol 2004;7:31-7.
6 Gnarpe J, Eriksson K. Sample preparation for Chlamydia pneumoniae PCR. APMIS 1995;103:307-8.   DOI   ScienceOn
7 Tong CY, Sillis M. Detection of Chlamydia pneumoniae and Chlamydia psittaci in sputum samples by PCR. J Clin Pathol 1993;46:313-7.   DOI   ScienceOn
8 Lee WK. Chlamydia pneumoniae and Atherosclerosis. Korean J Clin Microbiol 2001;4:78-81.
9 Lee EM, Oh DJ, Hwang GS, Ahn JC, Song WH, Lim DS, et al. Chronic chlamydia pneumoniae infection as a risk factor for acute myocardial infarction in Korea. Korean Circ J 2000;30:407-15.   DOI
10 Irwin RS, Rosen MJ, Braman SS. Cough. A comprehensive review. Arch Intern Med 1977;137:1186-91.   DOI   ScienceOn
11 Irwin RS, Corrao WM, Pratter MR. Chronic persistent cough in the adult: the spectrum and frequency of causes and successful outcome of specific therapy. Am Rev Respir Dis 1981;123:413-7.
12 Irwin RS, Curley FJ, French CL. Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Am Rev Respir Dis 1990;141:640-7.   DOI   ScienceOn
13 Brightling CE, Ward R, Goh KL, Wardlaw AJ, Pavord ID. Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med 1999;160: 406-10.   DOI   ScienceOn
14 Grayston JT, Wang S. New knowledge of chlamydiae and the diseases they cause. J Infect Dis 1975;132:87-105.   DOI   ScienceOn
15 Kuo CC, Jackson LA, Campbell LA, Grayston JT. Chlamydia pneumoniae (TWAR). Clin Microbiol Rev 1995; 8:451-61.
16 Park J, Kim JK, Rheem I, Kim J. Evaluation of Seeplex Pneumobacter multiplex PCR kit for the detection of respiratory bacterial pathogens in pediatric patients. Korean J Lab Med 2009;29:307-13.   DOI   ScienceOn
17 Park SE, Choi SE, Jung HS, Kwak YH, Lee HJ. Detection of Chlamydia pneumoniae by use of the nested polymerase chain reaction in children with lower respiratory tract infection. Korean J Infect Dis 1999; 31:197-202.
18 Birkebaek NH, Jensen JS, Seefeldt T, Degn J, Huniche B, Andersen PL, et al. Chlamydia pneumoniae infection in adults with chronic cough compared with healthy blood donors. Eur Respir J 2000;16:108-11.   DOI   ScienceOn
19 Boman J, Gaydos CA, Quinn TC. Molecular diagnosis of Chlamydia pneumoniae infection. J Clin Microbiol 1999;37:3791-9.
20 Hammerschlag MR, Chirgwin K, Roblin PM, Gelling M, Dumornay W, Mandel L, et al. Persistent infection with Chlamydia pneumoniae following acute respiratory illness. Clin Infect Dis 1992;14:178-82.   DOI   ScienceOn
21 Dowell SF, Peeling RW, Boman J, Carlone GM, Fields BS, Guarner J, et al. Standardizing Chlamydia pneumoniae assays: recommendations from the Centers for Disease Control and Prevention (USA) and the Laboratory Centre for Disease Control (Canada). Clin Infect Dis 2001;33:492-503.   DOI   ScienceOn
22 Hermann C, Gueinzius K, Oehme A, Von Aulock S, Straube E, Hartung T. Comparison of quantitative and semiquantitative enzyme-linked immunosorbent assays for immunoglobulin G against Chlamydophila pneumoniae to a microimmunofluorescence test for use with patients with respiratory tract infections. J Clin Microbiol 2004;42:2476-9.   DOI   ScienceOn
23 File TM Jr, Tan JS, Plouffe JF. The role of atypical pathogens: Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila in respiratory infection. Infect Dis Clin North Am 1998;12:569-92.   DOI   ScienceOn
24 Hahn DL, Anttila T, Saikku P. Association of Chlamydia pneumoniae IgA antibodies with recently symptomatic asthma. Epidemiol Infect 1996;117:513-7.   DOI   ScienceOn
25 Black PN, Scicchitano R, Jenkins CR, Blasi F, Allegra L, Wlodarczyk J, et al. Serological evidence of infection with Chlamydia pneumoniae is related to the severity of asthma. Eur Respir J 2000;15:254-9.   DOI   ScienceOn
26 Miyashita N, Kubota Y, Nakajima M, Niki Y, Kawane H, Matsushima T. Chlamydia pneumoniae and exacerbations of asthma in adults. Ann Allergy Asthma Immunol 1998;80:405-9.   DOI   ScienceOn
27 Black PN, Blasi F, Jenkins CR, Scicchitano R, Mills GD, Rubinfeld AR, et al. Trial of roxithromycin in subjects with asthma and serological evidence of infection with Chlamydia pneumoniae. Am J Respir Crit Care Med 2001;164:536-41.   DOI   ScienceOn
28 Ferrari M, Poli A, Olivieri M, Verlato G, Tardivo S, Nicolis M, et al. Respiratory symptoms, asthma, atopy and Chlamydia pneumoniae IgG antibodies in a general population sample of young adults. Infection 2002; 30:203-7.   DOI   ScienceOn
29 Hyman CL, Augenbraun MH, Roblin PM, Schachter J, Hammerschlag MR. Asymptomatic respiratory tract infection with Chlamydia pneumoniae TWAR. J Clin Microbiol 1991;29:2082-3.
30 Block S, Hedrick J, Hammerschlag MR, Cassell GH, Craft JC. Mycoplasma pneumoniae and Chlamydia pneumoniae in pediatric community-acquired pneumonia: comparative efficacy and safety of clarithromycin vs. erythromycin ethylsuccinate. Pediatr Infect Dis J 1995;14:471-7.   DOI   ScienceOn