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http://dx.doi.org/10.4046/trd.2010.69.5.361

Characteristics of Difficult to Treat Asthma in Korea  

Yoo, Kwang-Ha (Department of Internal Medicine, Konkuk University College of Medicine)
Lee, Kwan-Ho (Department of Internal Medicine, Yeungnam University College of Medicine)
Uh, Soo-Taek (Department of Internal Medicine, Soonchunhyang University College of Medicine)
Park, Yong-Bum (Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine)
Rhee, Yang-Keun (Department of Internal Medicine, Chonbuk National University College of Medicine)
Oh, Yeon-Mok (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.69, no.5, 2010 , pp. 361-367 More about this Journal
Abstract
Background: Difficult-to-treat asthma afflicts a small percentage of the asthma population. However, these patients remain refractory to treat, and account for 40% to 50% of the health costs of asthma treatment, incurring significant morbidity. We conducted a multi-center cross-sectional study to characterize difficult-to-treat asthma in Korea. Methods: Subjects with difficult-to-treat asthma and subjects with controlled asthma were recruited from 5 outpatient clinics of referral hospitals. We reviewed medical records of previous 6 months and obtained patient-reported questionnaires composed of treatment compliance, asthma control, and instruments for stress, anxiety, and depression. Results: We recruited 21 subjects with difficult-to-treat asthma and 110 subjects with controlled asthma into the study. The subjects with difficult-to-treat asthma were associated with longer treatment periods, more increased health care utilization, more medication (oral corticosteroids, number of medication), and more anxiety disorder compared to those of well-controlled asthmatics. There was no difference in age, gender, history of allergy, serum IgE, blood eosinophil count, or body mass index between the 2 groups. Conclusion: Difficult-to-treat asthma is characterized by increased health care utilization and more co-morbidity of anxiety.
Keywords
Asthma; Therapeutics; Korea; Adrenal Cortex Hormones; Comorbidity;
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