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http://dx.doi.org/10.4046/trd.2009.67.2.135

A Case of Severe Human Metapneumovirus Pneumonia Requiring Mechanical Ventilation in an Immunocompetent Adult  

Lim, Hyo-Jeong (Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine)
Lee, Jin Woo (Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine)
Park, Young Sik (Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine)
Kim, Nak-Hyun (Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine)
Kim, Moonsuk (Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine)
Yim, Jae-Joon (Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine)
Yang, Seok-Chul (Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine)
Yoo, Chul-Gyu (Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine)
Kim, Young Whan (Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine)
Han, Sung Koo (Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine)
Shim, Young-Soo (Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine)
Lee, Sang-Min (Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.67, no.2, 2009 , pp. 135-139 More about this Journal
Abstract
Human metapneumovirus (hMPV) is a recently recognized human respiratory pathogen, which is known to be associated with upper and lower respiratory tract infections mainly in children, immunocompromised patients, and the elderly. The clinical manifestations of hMPV infections are similar to those of the human respiratory syncytial virus infection, which range from mild upper respiratory tract infection to severe bronchiolitis and pneumonia. Recently, hMPV has come to be thought of as the cause a similar spectrum of disease in adults as that seen in children; however, most of the reports of hMPV infections have focused on infection in children. We report a case of severe hMPV pneumonia requiring mechanical ventilation in an immunocompetent adult in Korea.
Keywords
Metapneumovirus; Pneumonia; Respiratory insufficiency;
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1 Hamelin ME, Cote S, Laforge J, Lampron N, Bourbeau J, Weiss K, et al. Human metapneumovirus infection in adults with community-acquired pneumonia and exacerbation of chronic obstructive pulmonary disease. Clin Infect Dis 2005;41:498-502   DOI   ScienceOn
2 Carrat F, Leruez-Ville M, Tonnellier M, Baudel JL, Deshayes J, Meyer P, et al. A virologic survey of patients admitted to a critical care unit for acute cardiorespiratory failure. Intensive Care Med 2006;32:156-9   DOI   ScienceOn
3 Cameron RJ, de Wit D, Welsh TN, Ferguson J, Grissell TV, Rye PJ. Virus infection in exacerbations of chronic obstructive pulmonary disease requiring ventilation. Intensive Care Med 2006;32:1022-9   DOI   ScienceOn
4 Englund JA, Boeckh M, Kuypers J, Nichols WG, Hackman RC, Morrow RA, et al. Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients. Ann Intern Med 2006;144:344-9   DOI   PUBMED   ScienceOn
5 Johnstone J, Majumdar SR, Fox JD, Marrie TJ. Human metapneumovirus pneumonia in adults: results of a prospective study. Clin Infect Dis 2008;46:571-4   DOI   ScienceOn
6 Biacchesi S, Skiadopoulos MH, Yang L, Lamirande EW, Tran KC, Murphy BR, et al. Recombinant human Metapneumovirus lacking the small hydrophobic SH and/or attachment G glycoprotein: deletion of G yields a promising vaccine candidate. J Virol 2004;78:12877-87   DOI   ScienceOn
7 Herd KA, Mahalingam S, Mackay IM, Nissen M, Sloots TP, Tindle RW. Cytotoxic T-lymphocyte epitope vaccination protects against human metapneumovirus infection and disease in mice. J Virol 2006;80:2034-44   DOI   ScienceOn
8 Wyde PR, Chetty SN, Jewell AM, Boivin G, Piedra PA. Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro. Antiviral Res 2003;60:51-9   DOI   ScienceOn
9 Deffrasnes C, Hamelin ME, Boivin G. Human metapneumovirus. Semin Respir Crit Care Med 2007;28:213-21   DOI   ScienceOn
10 Kamboj M, Gerbin M, Huang CK, Brennan C, Stiles J, Balashov S, et al. Clinical characterization of human metapneumovirus infection among patients with cancer. J Infect 2008;57:464-71   DOI   ScienceOn
11 Sivaprakasam V, Collins TC, Aitken C, Carman WF. Life-threatening human metapneumovirus infections in West of Scotland. J Clin Virol 2007;39:234-7   DOI   ScienceOn
12 Chung JY, Han TH, Kim BE, Kim CK, Kim SW, Hwang ES. Human metapneumovirus infection in hospitalized children with acute respiratory disease in Korea. J Korean Med Sci 2006;21:838-42   DOI   ScienceOn
13 Pabbaraju K, Wong S, McMillan T, Lee BE, Fox JD. Diagnosis and epidemiological studies of human metapneumovirus using real-time PCR. J Clin Virol 2007;40:186-92   DOI   ScienceOn
14 Falsey AR. Human metapneumovirus infection in adults. Pediatr Infect Dis J 2008;27:S80-3   DOI   PUBMED   ScienceOn
15 Johnstone J, Majumdar SR, Fox JD, Marrie TJ. Viral infection in adults hospitalized with community-acquired pneumonia: prevalence, pathogens, and presentation. Chest 2008;134:1141-8   DOI   ScienceOn
16 Ulbrandt ND, Ji H, Patel NK, Riggs JM, Brewah YA, Ready S, et al. Isolation and characterization of monoclonal antibodies which neutralize human metapneumovirus in vitro and in vivo. J Virol 2006;80:7799-806   DOI   ScienceOn
17 Larcher C, Geltner C, Fischer H, Nachbaur D, Muller LC, Huemer HP. Human metapneumovirus infection in lung transplant recipients: clinical presentation and epidemiology. J Heart Lung Transplant 2005;24:1891-901   DOI   ScienceOn
18 Williams JV, Martino R, Rabella N, Otegui M, Parody R, Heck JM, et al. A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections. J Infect Dis 2005;192:1061-5   DOI   ScienceOn
19 Hamelin ME, Prince GA, Boivin G. Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection. Antimicrob Agents Chemother 2006;50:774-7   DOI   ScienceOn
20 Van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 2001;7:719-24   DOI   ScienceOn