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http://dx.doi.org/10.4046/trd.2009.66.5.374

A Case of Churg-Strauss Syndrome with Interstinal Perforation  

Park, Jung Hoon (Department of Internal Medicine, School of Medicine, Soonchunhyang University)
Jung, Yun Seok (Department of Internal Medicine, School of Medicine, Soonchunhyang University)
Kim, Yang Ki (Department of Internal Medicine, School of Medicine, Soonchunhyang University)
Lee, Young Mok (Department of Internal Medicine, School of Medicine, Soonchunhyang University)
Hwang, Jung Hwa (Department of Radiology, School of Medicine, Soonchunhyang University)
Kim, Ki-Up (Department of Internal Medicine, School of Medicine, Soonchunhyang University)
Kim, Dong Won (Department of Pathology, School of Medicine, Soonchunhyang University)
Uh, Soo-Taek (Department of Internal Medicine, School of Medicine, Soonchunhyang University)
Kim, Jae Jun (Department of Surgery, School of Medicine, Soonchunhyang University)
Publication Information
Tuberculosis and Respiratory Diseases / v.66, no.5, 2009 , pp. 374-379 More about this Journal
Abstract
Churg-Strauss syndrome (CSS) or allergic granulomatous angiitis is a rare syndrome that is characterized by hypereosinophilic systemic necrotizing vasculitis affecting small- to medium-sized arteries and veins. In general, it occurs in individuals with pre-existing allergic asthma. When CSS appears in patients, it has the following characteristics: eosinophilia of more than 10% in peripheral blood, paranasal sinusitis, pulmonary infiltrates, histological proof of vasculitis with extravascular eosinophils, and mononeuritis multiplex or polyneuropathy. Therapeutic trials dedicated to Churg-Strauss syndrome have been limited due to the rarity of this disorder and the difficulty in making a histological diagnosis. Proper treatment of patients with CSS is not widely known. In this case study, we report on our experience with an unusual patient case, characterized by purpura and a perforation of the small intestine after inadequate steroid therapy.
Keywords
Churg-Strauss syndrome; Asthma; Intestinal perforation; Eosinophilic infiltration;
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1 Keogh KA, Specks U. Churg-Strauss syndrome: update on clinical, laboratory and therapeutic aspects. Sarcoidosis Vasc Diffuse Lung Dis 2006;23:3-12   PUBMED
2 Kurita M, Niwa Y, Hamada E, Hata Y, Oshima M, Mutoh H, et al. Churg-Strauss syndrome (allergic granulomatous angiitis) with multiple perforating ulcers of the small intestine, multiple ulcers of the colon, and mononeuritis multiplex. J Gastroenterol 1994;29:208-13   DOI   ScienceOn
3 Lanham JG, Elkon KB, Pusey CD, Hughes GR. Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg-Strauss syndrome. Medicine (Baltimore) 1984;63:65-81   PUBMED
4 Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP, et al. The American college of rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum 1990;33:1094-100   DOI   PUBMED   ScienceOn
5 Guillevin L, Cohen P, Gayraud M, Lhote F, Jarrousse B, Casassus P. Churg-Strauss syndrome: clinical study and long-term follow-up of 96 patients. Medicine (Baltimore) 1999;78:26-37   DOI   ScienceOn
6 Guillevin L, Lhote F, Gayraud M, Cohen P, Jarrousse B, Lortholary O, et al. Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome: a prospective study in 342 patients. Medicine (Baltimore) 1996;75:17-28   DOI   ScienceOn
7 Kim YB, Choi SW, Park IS, Han JY, Hur YS, Chu YC. Churg-Strauss syndrome with perforating ulcers of the colon. J Korean Med Sci 2000;15:585-8   DOI   PUBMED
8 Vaglio A, Martorana D, Maggiore U, Grasselli C, Zanetti A, Pesci A, et al. HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome. Arthritis Rheum 2007;56:3159-66   DOI   ScienceOn
9 Jung SH, Kim KH, Nam SM, Park HC, Chu HK, Whang IS, et al. A case of Churg-Strauss syndrome with manifestations of esophageal ulcer, acute acalculous cholecystitis and ischemic colitis. Korean J Med 1993;45:369-75
10 Churg J, Strauss L. Allergic granulomatosis, allergic angiitis, and periarteritis nodosa. Am J Pathol 1951;27:277-301   PUBMED
11 Chumbley LC, Harrison EG Jr, DeRemee RA. Allergic granulomatosis and angiitis (Churg-Strauss syndrome): report and analysis of 30 cases. Mayo Clin Proc 1977;52:477-84   PUBMED
12 Kaneki T, Kawashima A, Hayano T, Honda T, Kubo K, Koizumi T, et al. Churg-Strauss syndrome (allergic granulomatous angitis) presenting with ileus caused by ischemic ileal ulcer. J Gastroenterol 1998;33:112-6   DOI   ScienceOn
13 Lee YK, Choi KW, Lee CY, Kim Hs, Kim KH, Kim YH. A case of Churg-Strauss syndrome associated with small bowel perforation following high dose systemic steroid intravenous injection. Korean J Dermatol 2008;46:950-4
14 Oh MJ, Ji SH, Lim DH, Min TH, Lee BJ, Choi DC, et al. A case of intestinal perforation in Churg-Strauss syndrome patient. Korean J Med 2004;67:208-12
15 Kim JH, Yoon KY, Shin YM. Churg-Strauss syndrome with multiple small bowel perforation. J Korean Surg Soc 1998;54:148-52