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http://dx.doi.org/10.4046/trd.2009.66.3.186

Prevalence and Risk Factors of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease  

Sim, Yun Su (Department of Internal Medicine, Ewha Womans University School of Medicine)
Lee, Jin Hwa (Department of Internal Medicine, Ewha Womans University School of Medicine)
Ryu, Yon Ju (Department of Internal Medicine, Ewha Womans University School of Medicine)
Chun, Eun Mi (Department of Internal Medicine, Ewha Womans University School of Medicine)
Chang, Jung Hyun (Department of Internal Medicine, Ewha Womans University School of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.66, no.3, 2009 , pp. 186-191 More about this Journal
Abstract
Background: Osteoporosis is a significant comorbidity in patients with chronic obstructive pulmonary disease (COPD). This study examined the prevalence and risk factors associated with osteoporosis in patients with COPD. Methods: The bone mineral densities (BMDs) of the lumbar spine and femoral bone were measured in 53 patients with clinically stable COPD and 41 age- and gender-matched control subjects showing a normal lung function. Osteoporosis was defined as a T-score $\leq$-2.5. The subjects' clinical characteristics and laboratory data were reviewed, and multiple logistic regression analysis was used to identify the risk factors associated with osteoporosis in COPD patients. Results: The prevalence of osteoporosis was 47% and 32% in the COPD patients and controls, respectively. In particular, using the femoral neck T-score, the prevalence of osteoporosis in COPD patients was higher than that in the controls (26% vs. 5%; p=0.006). The average T-score of the lumbar spine (p=0.025) and femoral neck of COPD patients were significantly lower than those of the controls (p=0.001). The forced expiratory volume in the 1 second ($FEV_1$) % predicted (p=0.019; odds ratio [OR], 0.955; 95% confidence interval [CI], 0.919-0.993) and age (p=0.024; OR, 1.144; 95% CI, 1.018-1.287) were independently associated with osteoporosis in patients with COPD. Conclusion: Using the femoral neck T-score, the prevalence of osteoporosis in patients with COPD was higher than the age-and gender-matched controls. A lower $FEV_1$ and older age further increase the risk of osteoporosis in patients with COPD.
Keywords
Chronic obstructive pulmonary disease; Osteoporosis; Prevalence; Risk factor; Lung function;
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