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Improvement of Pulmonary Function after Administration of Azithromycin in a Patient with Bronchiolitis Obliterans: a Case Report  

Oh, Ji Hye (Department of Internal Medicine. Catholic University of Daegu School of Medicine)
Kim, Kyung Chan (Department of Internal Medicine. Catholic University of Daegu School of Medicine)
Kim, Sung Woo (Department of Internal Medicine. Catholic University of Daegu School of Medicine)
Hyun, Dae Sung (Department of Internal Medicine. Catholic University of Daegu School of Medicine)
Lee, Sang Chae (Department of Internal Medicine. Catholic University of Daegu School of Medicine)
Bae, Sung Hwa (Department of Internal Medicine. Catholic University of Daegu School of Medicine)
Jung, Kyung Jae (Department of Radiology, Catholic University of Daegu School of Medicine)
Kwon, Kun Young (Department of Pathology, Keimyung University School of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.65, no.5, 2008 , pp. 410-415 More about this Journal
Abstract
Bronchiolitis obliterans (BO) is a serious noninfectious complication following an allogeneic bone marrow transplant (BMT). A 21-year-old female received an allogeneic BMT as a treatment for myelodyplastic syndrome. Four months after the BMT, progressive dyspnea developed and BO was also diagnosed by a lung biopsy. The patient was administered steroid and immunosuppressive agents for 1 year but there was no improvement in pulmonary function. Azithromycin was prescribed (500 mg q.d. for 3 days followed by 250 mg three time a week) because macrolides might decrease the inflammatory reaction leading to BO. The patient's pulmonary function improved after administration of azithromycin for 1 year. The forced expiratory volume in a one second ($FEV_1$) increase was 220 mL (28.2%) and the forced vital capacity (FVC) increase was 460 mL (25.7%). We report the improvement in the pulmonary function after the administration of azithromycin for 1 year in a patient with BO after a BMT.
Keywords
Bone marrow transplantation; Bronchiolitis obliterans; Pulmonary function; Azithromycin;
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