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Health-related Quality of Life Measurement with St. George's Respiratory Questionnaire in Post-tuberculous Destroyed Lung  

Lee, Byoung Hoon (Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine)
Kim, Young Sam (Department of Internal Medicine, Yonsei University College of Medicine)
Lee, Ki Deok (Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine)
Lee, Jae Hyung (Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine)
Kim, Sang-Hoon (Department of Internal Medicine, Eulji General Hospital, Eulji University School of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.65, no.3, 2008 , pp. 183-190 More about this Journal
Abstract
Background: The control of active pulmonary tuberculosis is still an issue in community medicine. But there are also considerable needs for supportive management of symptomatic patients with post-tuberculous destroyed lung. Few studies have evaluated clinical characteristics and health-related quality of life in patients with post-tuberculous destroyed lung. Methods: We evaluated lung function, exercise tolerance, HRCT and health-related quality of life measurements using the Korean version of St. George's Respiratory Questionnaire (SGRQ) in 22 patients with parenchymal damage to more than a half of one lung due to pulmonary tuberculosis. Results: In the pulmonary function test, mixed defects and obstructive defects were observed in 10 (45.0%) and 9 (40.9%) of patients, respectively. In the cardiopulmonary exercise test, the mean $VO_2max%$ predicted ($39.0%{\pm}10.9%$) and $O_2$ pulse% predicted ($61.3%{\pm}13.6%$) were markedly decreased. In the SGRQ, the impact score (mean $27.8{\pm}18.5$) was significantly lower than the symptom score (mean $53.9{\pm}20.9$) or activity score (mean $50.8{\pm}27.3$) (p<0.05, p<0.01). Cronbach's alpha coefficient value for reliability was more than 0.7 for each subscale and total score. The total score showed a significant negative correlation with $FEV_1%$ predicted (r=-0.46, p<0.05) and $SaO_2$ (r=-0.60, p<0.05). On HRCT, a median of 9 (range 5~15) bronchopulmonary segments were destroyed by less than half, which significantly correlated with SGRQ total score (r=-0.52, p=0.02). Conclusion: The reliability and validity of the Korean version of the SGRQ was acceptable for the measurement of health-related quality of life in patients with post-tuberculous destroyed lung.
Keywords
Tuberculosis; Quality of life; Pulmonary function test;
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