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The Clinical and Histopathologic Features according to Loss of LKB1 Protein Expression on Primary Lung Cancer  

Hwang, Ki Eun (Department of Internal Medicine, College of Medicine, Wonkwang University)
Jo, Hyang-Jeong (Department of Pathology, College of Medicine, Wonkwang University)
Lee, Kang Kyoo (Department of Therapeutic Radiology and Oncology, College of Medicine, Wonkwang University)
Sim, Hyeok (Department of Internal Medicine, College of Medicine, Wonkwang University)
Song, Jung Sup (Department of Internal Medicine, College of Medicine, Wonkwang University)
Shin, Jeong Hyun (Department of Internal Medicine, College of Medicine, Wonkwang University)
Shin, Seong Nam (Department of Internal Medicine, College of Medicine, Wonkwang University)
Park, Seong-Hoon (Department of Radiology, College of Medicine, Wonkwang University)
Hong, Kyeong-Man (Research Institute, National Cancer Center)
Park, Jung-Hyun (Department of Internal Medicine, College of Medicine, Wonkwang University)
Jeong, Jong-Hoon (Department of Internal Medicine, College of Medicine, Wonkwang University)
Kim, Hui Jung (Department of Internal Medicine, College of Medicine, Wonkwang University)
Kim, Hak-Ryul (Department of Internal Medicine, College of Medicine, Wonkwang University)
Yang, Sei-Hoon (Department of Internal Medicine, College of Medicine, Wonkwang University)
Jeong, Eun-Taik (Department of Internal Medicine, College of Medicine, Wonkwang University)
Publication Information
Tuberculosis and Respiratory Diseases / v.64, no.5, 2008 , pp. 362-368 More about this Journal
Abstract
Background: LKB1(STK11) is a serine/threonine kinase that functions as a tumor growth suppressor. The functions of LKB1 in lung cancer are not completely understood. This study evaluated the relationship between LKB1 protein expression and the clinicopathological features in lung cancer tissues. Methods: The expression of LKB1 was studied in paraffin-embedded tumor blocks, which were obtained from 77 patients who had undergone surgery at Wonkwang University Hospital. The expression of the LKB1 protein was considered positive if the staining intensity in the tumor tissue adjacent to the normal airway epithelium was >30%. Results: The LKB1 expression was positive in 31 (40%) of samples. Loss of LKB1 expression was significantly associated with being male, smoking history, and squamous cell carcinoma. In the peripheral sites, the loss of LKB1 expression was strongly associated with a smoking history. A loss of LKB1 expression was more frequently associated with progression according to TNM staging, particularly more than T2, N progression. Conclusion: There was a significant relationship between the loss of the LKB1 protein and gender, smoking history, and histological type in primary lung cancer. Although LKB1 expression was not found to be a significant prognostic factor, further studies with a larger cohort of patient's lung cancer tissue samples will be needed to confirm this.
Keywords
LKB1; Gender; Smoking; Lung cancer;
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1 Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74-108   DOI   ScienceOn
2 Diez M, Pollán M, Maestro M, Torres A, Ortega D, Gómez A, et al. Prediction of recurrence by quantification of p185neu protein in non-small cell lung cancer tissue. Br J Cancer 1997;75:684-9   DOI   ScienceOn
3 Hemminki A, Tomlinson I, Markie D, Järvinen H, Sistonen P, Björkqvist AM, et al. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat Genet 1997;15:87-90   DOI   ScienceOn
4 Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet 1998;18:38-43   DOI   ScienceOn
5 Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, et al. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell 2001;7:1307-19   DOI   ScienceOn
6 Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007;448:807-10   DOI   ScienceOn
7 Sanchez-Cespedes M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM, et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 2002;62:3659-62
8 Ghaffar H, Sahin F, Sanchez-Cepedes M, Su GH, Zahurak M, Sidransky D, et al. LKB1 protein expression in the evolution of glandular neoplasia of the lung. Clin Cancer Res 2003;9:2998-3003
9 Avizienyte E, Loukola A, Roth S, Hemminki A, Tarkkanen M, Salovaara R, et al. LKB1 somatic mutations in sporadic tumors. Am J Pathol 1999;154:677-81   DOI   ScienceOn
10 Minna JD, Ginsberg RJ, Ihde DC. Chapter 30. Cancer of lung. In: DeVita VT, Hellman S, Rosenberg SA, editors. Cancer: principles and practice of oncology. 5th ed. Philadelphia: Lippincott-Raven Pub.; 1997. p. 849
11 Shen Z, Wen XF, Lan F, Shen ZZ, Shao ZM. The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. Clin Cancer Res 2002;8:2085- 90
12 Fraumeni JF JR, Schottenfeld D, Searle JG. Cancer epidemiology and prevention. 2nd ed. New York: Oxford University Press; 1996
13 Tiainen M, Ylikorkala A, Makela TP. Growth suppression by Lkb1 is mediated by a G1 cell cycle arrest. Proc Natl Acad Sci USA 1999;96:9248-51   DOI
14 Sanchez-Cespedes M, Ahrendt SA, Piantadosi S, Rosell R, Monzo M, Wu L, et al. Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers. Cancer Res 2001;61:1309-13
15 Cox G, Jones JL, Andi A, Waller DA, O'Byrne KJ. A biological staging model for operable non-small cell lung cancer. Thorax 2001;56:561-6   DOI
16 Parkin DM, Pisani P, Lopez AD, Masuyer E. At least one in seven cases of cancer is caused by smoking. Int J Cancer 1994;59:494-504   DOI   ScienceOn
17 Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998;391:184-7   DOI   ScienceOn
18 Onozato R, Kosaka T, Achiwa H, Kuwano H, Takahashi T, Yatabe Y, et al. LKB1 gene mutations in Japanese lung cancer patients. Cancer Sci 2007;98:1747-51   DOI   ScienceOn
19 Boardman LA, Thibodeau SN, Schaid DJ, Lindor NM, McDonnell SK, Burgart LJ, et al. Increased risk for cancer in patients with the Peutz-Jeghers syndrome. Ann Intern Med 1998;128:896-9   DOI