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A Case of Diffuse Alveolar Hemorrhage Associated with Cytomegalovirus Pneumonia  

Cho, Yong Duck (Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University School of Medicine)
Choi, Hye Sook (Department of Pulmonary and Critical Care Medicine, Dongguk University College of Medicine)
Park, Myung Jae (Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University School of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.64, no.4, 2008 , pp. 309-313 More about this Journal
Abstract
Cytomegalovirus (CMV) pneumonia is a serious opportunistic infection in an immunocompromised host such as an AIDS patient or transplant recipient undergoing immunosuppressive therapy. Diffuse alveolar hemorrhage (DAH) is a relatively uncommon condition and it occurs most often in patients with systemic autoimmune disease. However, various types of infectious pneumonia with Mycoplsma hominis, Stenotrophomonas maltophilia and Pneumocystis jirovecii have been reported to be associated with the development of DAH. The association of CMV infection with the development of DAH has rarely been reported. We experienced a case of DAH associated CMV pneumonia and the patient was successfully treated with the use of antiviral agents and steroids.
Keywords
Cytomegalovirus infections; Diffuse alveolar hemorrhage;
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1 Tsushima K, Koyama S, Takematsu H, Okada K, Hata S, Ichiyoshi T, et al. Massive pulmonary hemorrhage due to cytomegalovirus infection in a Japanese patient with alpha-1-antitrypsin-deficient emphysema. Respiration 1999;66:373-6   DOI   ScienceOn
2 Meyers JD, Flournoy N, Thomas ED. Risk factors for cytomegalovirus infection after human marrow transplantation. J Infect Dis 1986;153:478-88   DOI   ScienceOn
3 Kahn FW, Jones JM, England DM. Diagnosis of pulmonary hemorrhage in the immunocompromised host. Am Rev Respir Dis 1987;136:155-60   DOI   ScienceOn
4 Kane JR, Shenep JL, Krance RA, Hurwitz CA. Diffuse alveolar hemorrhage associated with Mycoplasma hominis respiratory tract infection in a bone marrow transplant recipient. Chest 1994;105:1891-2   DOI   ScienceOn
5 Vincent B, Flahault A, Antoine M, Wislez M, Parrot A, Mayaud C, et al. AIDS-related alveolar hemorrhage: a prospective study of 273 BAL procedures. Chest 2001; 120:1078-84   DOI   ScienceOn
6 Magro C, Ali N, Williams JD, Allen JN, Ross P Jr. Cytomegalovirus-associated pulmonary septal capillary injury sine inclusion body change: a distinctive cause of occult or macroscopic pulmonary hemorrhage in the immunocompetent host. Appl Immunohistochem Mol Morphol 2005;13:268-72   DOI   ScienceOn
7 De Lassence A, Fleury-Feith J, Escudier E, Beaune J, Bernaudin JF, Cordonnier C. Alveolar hemorrhage. Diagnostic criteria and results in 194 immunocompromised hosts. Am J Respir Crit Care Med 1995;151:157-63   DOI   ScienceOn
8 Shin HJ, Kim HK, Kim HS. The usefulness of PCR and early antigen immunostaining as a rapid identification method of cytomegalovirus infection. Kor J Clin Pathol 1998;18:452-7
9 Ortin X, Jaen-Martinez J, Rodriguez-Luaces M, Alvaro T, Font L. Fatal pulmonary hemorrhage in a patient with myelodysplastic syndrome and fulminant pneumonia caused by Stenotrophomonas maltophilia. Infection 2007;35:201-2   DOI
10 Chang WI, Oh JH, Han HW, Kim SH, Kim YS, Son SH, et al. Fatal cytomegalovirus pneumonia in a immunocompetent patient. Korean J Infect Dis 2000;32:78-81
11 Heo WY, Jung WJ, Lee YJ, Park SD, Lee SW, Park MJ, et al. A case of pneumocystis carinii pneumonia with diffuse pulmonary hemorrhage. Tuberc Respir Dis 2004;57:372-6   DOI
12 Magro CM, Crowson AN, Ferri C. Cytomegalovirus-associated cutaneous vasculopathy and scleroderma sans inclusion body change. Hum Pathol 2007;38:42-9   DOI   ScienceOn
13 Herry I, Cadranel J, Antoine M, Meharzi J, Michelson S, Parrot A, et al. Cytomegalovirus-induced alveolar hemorrhage in patients with AIDS: a new clinical entity? Clin Infect Dis 1996;22:616-20   DOI   ScienceOn
14 Riddell SR. Pathogenesis of cytomegalovirus pneumonia in immunocompromised hosts. Semin Respir Infect 1995;10:199-208
15 Ham HS, No GH, Kang EH, Kang SJ, An CH, Suh GY, et al. The clinical characteristics of diffuse alveolar hemorrhage: a retrospective study of 21 cases. Tuberc Respir Dis 2000;49:614-23   DOI