Diagnosis of Malignant Pleural Effusion by using Aberrant Methylation of p16 and RARB2
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Rha, Seo Hee
(Department of Pathology, Dong-A University College of Medicine)
Lee, Su Mi (Department of Internal Medicine, Dong-A University College of Medicine) Koo, Tae Hyoung (Department of Internal Medicine, Dong-A University College of Medicine) Shin,, Bong Chul (Department of Internal Medicine, Dong-A University College of Medicine) Huh, Jung Hun (Department of Internal Medicine, Dong-A University College of Medicine) Um, Soo Jung (Department of Internal Medicine, Dong-A University College of Medicine) Yang, Doo Kyung (Department of Internal Medicine, Dong-A University College of Medicine) Lee, Soo-Keol (Department of Internal Medicine, Dong-A University College of Medicine) Son, Choonhee (Department of Internal Medicine, Dong-A University College of Medicine) Roh, Mee Sook (Department of Pathology, Dong-A University College of Medicine) Bae, Ho-Jeong (Department of Pathology, Dong-A University College of Medicine) Kim, Ki Nam (Department of Radiology, Dong-A University College of Medicine) Lee, Ki Nam (Department of Radiology, Dong-A University College of Medicine) Choi, Pil Jo (Department of Thoracic and Cardiovascular Surgery, Dong-A University College of Medicine) |
1 | Korea National Statistical Office. Annual report on the cause of death statistics, 2005. Daejeon, Korea: Korea National Statistical Office; 2005. available from: http://www.cancer.go.kr/nciapps/user/basicinfo/ gcancer_main.jsp |
2 | Light RW. Clinical practice. Pleural effusion. N Engl J Med 2002;346:1971-7 DOI ScienceOn |
3 | Digel W, Lubbert M. DNA methylation disturbances as novel therapeutic target in lung cancer: preclinical and clinical results. Crit Rev Oncol Hematol 2005;55:1-11 DOI ScienceOn |
4 |
Belinsky SA, Nikula KJ, Palmisano WA, Michels R, Saccomanno G, Gabrielson E, et al. Aberrant methylation of P |
5 |
Grote HJ, Schmiemann V, Geddert H, Rohr UP, Kappes R, Gabbert HE, et al. Aberrant promoter methylation of |
6 | Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 1996;93:9821-6 DOI |
7 | Postmus PE, Brambilla E, Chansky K, Crowley J, Goldstraw P, Patz EF Jr, et al. The IASLC lung cancer staging project: proposals for revision of the M descriptors in the forthcoming (seventh) edition of the TNM classification of lung cancer. J Thorac Oncol 2007;2: 686-93 DOI |
8 |
Gilliland FD, Harms HJ, Crowell RE, Li Y-F, Willink R, Belinsky SA. Glutathione s-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of |
9 | Katayama H, Hiraki A, Aoe K, Fujiwara K, Matsuo K, Maeda T, et al. Aberrant promoter methylation in pleural fluid DNA for diagnosis of malignant pleural effusion. Int J Cancer 2007;120:2191-5 DOI ScienceOn |
10 | Toyooka S, Toyooka KO, Maruyama R, Virmani AK, Girard L, Miyajima K, et al. DNA methylation profiles of lung tumors. Mol Cancer Ther 2001;1:61-7 |
11 | Ibanez de Caceres I, Battagli C, Esteller M, Herman JG, Dulaimi E, Edelson MI, et al. Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients. Cancer Res 2004;64:6476-81 DOI ScienceOn |
12 | Kim YC, Kwon YS, Oh IJ, Kim KS, Kim SY, Ryu JS, et al. National survey of lung cancer in Korea, 2005. J Lung Cancer 2007;6:67-73 DOI |
13 | Liu Y, Lee MO, Wang HG, Li Y, Hashimoto Y, Klaus M, et al. Retinoic acid receptor beta mediates the growth inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells. Mol Cell Biol 1996;16:1138-49 DOI |
14 | Fraipont F, Moro-Sibilot D, Michelland S, Brambilla E, Brambilla C, Favrot MC. Promoter methylation of genes in bronchial lavages: a marker for early diagnosis of primary and relapsing non-small cell lung cancer? Lung Cancer 2005;50:199-209 DOI ScienceOn |
15 | Otterson GA, Kratzke RA, Coxon A, Kim YW, Kaye FJ. Absence of p16INK4 protein is restricted to the subset of lung cancer cell lines that retains wildtype RB. Oncogene 1994;9:3375-8 |
16 | Poe RH, Israel RH, Utell MJ, Hall WJ, Greenblatt DW, Kallay MC. Sensitivity, specificity, and predictive values of closed pleural biopsy. Arch Intern Med 1984;144: 325-8 DOI |
17 | Houle B, Rochette-Egly C, Bradley WE. Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells. Proc Natl Acad Sci U S A 1993;90:985-9 DOI ScienceOn |
18 | Schmiemann V, Bocking A, Kazimirek M, Onofre AS, Gabbert HE, Kappes R, et al. Methylation assay for the diagnosis of lung cancer on bronchial aspirates: a cohort study. Clin Cancer Res 2005;11:7728-34 DOI ScienceOn |
19 | Cote S, Sinnett D, Momparler RL. Demethylation by 5-aza-2'-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor beta gene in human colon carcinoma cells. Anticancer Drugs 1998;9:743-50 DOI |
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