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A Case of Paraneoplastic Limbic Encephalitis Associated with Primary Adenocarcinoma of Lung  

Shin, Hyun Jong (Department of Internal Medicine, Hanyang University Guri Hospital)
Kim, Hyun Soo (Department of Internal Medicine, Hanyang University Guri Hospital)
Lim, Keum Nam (Department of Internal Medicine, Hanyang University Guri Hospital)
Noh, U Seok (Department of Internal Medicine, Hanyang University Guri Hospital)
Choi, Jung Hye (Department of Internal Medicine, Hanyang University Guri Hospital)
Kim, In Soon (Department of Internal Medicine, Hanyang University Guri Hospital)
Lee, Young Yeul (Department of Internal Medicine, Hanyang University Guri Hospital)
Park, Byeong Bae (Department of Internal Medicine, Hanyang University Guri Hospital)
Park, Dong Woo (Department of Radiology, Hanyang University Guri Hospital)
Publication Information
Tuberculosis and Respiratory Diseases / v.63, no.4, 2007 , pp. 382-386 More about this Journal
Abstract
Paraneoplastic limbic encephalitis is a rare disorder that is characterized by personality changes, irritability, depression, seizures, memory loss and dementia, and is commonly associated with small cell lung cancer. The cause is unknown but it is believed to be an autoimmune disorder that develops secondary to a carcinomatous process. We report a patient with the clinical feature consistent with limbic encephalitis. A 64-year-old women developed disorientation, memory loss and general weakness. She was diagnosed with NSCLC (adenocarcinoma) with a brain metastasis 1 year earlier and was treated with radiation and chemotherapy. Although the lung mass and brain metastatic lesions had improved, the brain T2-weighted MRI showed high signal intensity in the right temporal region. This lesion consisted of with limbic encephalitis and was negative to the other viral and immune markers. The patient's symptoms did not improve after steroid treatment. Our case demonstrated that a NSCLC (adenocarcinoma) also can be associated with paraneoplastic limbic encephalitis.
Keywords
Paraneoplastic Limbic encephalitis; Non-small cell Lung cancer;
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