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A Case of Pulmonary Alveolar Proteinosis with Spontaneous Resolution  

Nam, Seung Bum (Department of Internal Medicine, Korea Cancer Center Hospital)
Park, Kwang Young (Department of Internal Medicine, Korea Cancer Center Hospital)
Lee, Ho Jin (Department of Internal Medicine, Korea Cancer Center Hospital)
Jung, Jae Wook (Department of Internal Medicine, Korea Cancer Center Hospital)
Choi, Yoon Hee (Department of Internal Medicine, Korea Cancer Center Hospital)
Kim, Hyo Seok (Department of Internal Medicine, Korea Cancer Center Hospital)
Kim, Cheol Hyeon (Department of Internal Medicine, Korea Cancer Center Hospital)
Lee, Jae Cheol (Department of Internal Medicine, Korea Cancer Center Hospital)
Publication Information
Tuberculosis and Respiratory Diseases / v.63, no.3, 2007 , pp. 294-298 More about this Journal
Abstract
Pulmonary alveolar proteinosis is a rare disorder that is characterized by the abundant accumulation of surfactant-derived material within the alveolar spaces and distal bronchioles. Although the findings of homogenous ground-glass opacities overlaid by thickened septa, which form a "crazy paving" pattern on high-resolution computed tomography, can assist in making a diagnosis, a lung biopsy is usually required. This disorder has a variable clinical course, from spontaneous resolution to respiratory failure and death. While a whole lung lavage has been the standard treatment since the early 1960s, GM-CSF therapy has been attempted based on the recently suggested pathogenetic mechanism. We report a case of pulmonary alveolar proteinosis that resolved spontaneously after an open lung biopsy.
Keywords
Pulmonary alveolar proteinosis; Spontaneous resolution;
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