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Safety and Significance of Surgical Lung Biopsy for Interstitial Lung Disease  

Lee, Yu Jin (Department of Internal Medicine, College of Medicine, Chungnam National University)
Joung, Mi Kyong (Department of Internal Medicine, College of Medicine, Chungnam National University)
Chung, Chae Uk (Department of Internal Medicine, College of Medicine, Chungnam National University)
Park, Ji Won (Department of Internal Medicine, College of Medicine, Chungnam National University)
Shin, Ji Young (Department of Internal Medicine, College of Medicine, Chungnam National University)
Jung, Sun Young (Department of Internal Medicine, College of Medicine, Chungnam National University)
Lee, Jeong Eun (Department of Internal Medicine, College of Medicine, Chungnam National University)
Park, Hee Sun (Department of Internal Medicine, College of Medicine, Chungnam National University)
Jung, Sung Soo (Department of Internal Medicine, College of Medicine, Chungnam National University)
Kim, Ju Ock (Department of Internal Medicine, College of Medicine, Chungnam National University)
Kim, Sun Young (Department of Internal Medicine, College of Medicine, Chungnam National University)
Publication Information
Tuberculosis and Respiratory Diseases / v.63, no.1, 2007 , pp. 59-66 More about this Journal
Abstract
Background: Surgical lung biopsy is required to establish the etiology and stage of interstitial lung disease(ILD). and this procedure can be safe and meaningful for making clinical decisions. We wanted to determine the safety of surgical lung biopsy(SLB) in patients with interstitial lung disease(ILD). Methods: We conducted a retrospective review of 40 patients with suspected ILD and they underwent surgical lung biopsy from January 2001 to June 2006 at Chungnam University Hospital. We analyzed retrospectively according to their age, gender, pulmonary function, chest tube duration, the arterial blood gases, the procedural technique, and the requirement for supplemental oxygen and mechanical ventilation(MV) at the time of SLB. Results: The mean age of the patients was 56.4${\pm}$16.13 years(range: 21 to 77 years). Overall, the 30-day and 90-day mortality rates were 15% and 20%, respectively. The predictors of perioperative mortality were either the need for mechanical ventilation(MV) at the time of SLB or the need for supplemental oxygen prior to undergoing SLB. Among the 32 patients who were 90-day survivors, the proportion of those patients using the oxygen supplement was 28.1% (n=9). All 8 patients who were 90-day non-survivors used oxygen supplement (p=0.000). The use of the MV was 12.5% (n=4) in the 90-day survivors (n=32) and 62.5% (n=5) in the 90-day non-survivors (n=8); there was a significant difference between the 90-day survivors and non-survivors (p=0.000). Conclusion: Patients who require MV and supplemental oxygen are associated with an increased risk for death following SLB.
Keywords
Surgical lung biopsy; Interstitial lung disease; Safety;
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1 Mouroux J, Clary-Meinesz C, Padovani B, Perrin C, Rotomondo C, Chavaillon JM, et al. Efficacy and safety of videothoracoscopic lung biopsy in the diagnosis of interstitial lung disease. Eur J Cardiothorac Surg 1997;11:22-4   DOI   ScienceOn
2 Zompatori M, Bna C, Poletti V, Spaggiari E, Ormitti F, Calabro E, et al. Diagnostic imaging of diffuse infiltrative disease of the lung. Respiration 2004;66 71:4-19
3 Bensard DD, Mclntyre RC Jr, Waring BJ, Simon JS. Comparison of video thoracoscopic lung biopsy to open lung biopsy in the diagnosis of interstitial lung disease. Chest 1993;103:765-70   DOI   ScienceOn
4 Catterall JR, McCabe RE, Brooks RG, Remington JS. Open lung biopsy in patients with Hodgkin's disease and pulmonary infiltrates. Am Rev Respir Dis 1989; 139:1274-9   DOI   ScienceOn
5 Krasna MJ, White CS, Aisner SC, Templeton PA, McLaughlin JS. The role of thoracoscopy in the diagnosis of interstitial lung disease. Ann Thorac Surg 1995;59:348-51   DOI   ScienceOn
6 Crystal RG, Gadek JE, Ferrans VJ, Fulmer JD, Line BR, Hunninghake GW. Interstitial lung disease: current concepts of pathogenesis, staging and therapy. Am J Med 1981;70:542-68   DOI   ScienceOn
7 Popper HH. Which biopsies in diffuse infiltrative lung diseases and when are these necessary? Monaldi Arch Chest Dis 2001;56:446-52
8 Carnochan FM, Walker WS, Cameron EW. Efficacy of video assisted thoracoscopic lung biopsy: an historical comparison with open lung biopsy. Thorx 1994;49:361-3   DOI   ScienceOn
9 Kramer MR, Berkman N, Mintz B, Godfrey S, Saute M, Amir G. The role of open lung biopsy in the management and outcome of patients with diffuse lung disease. Ann Thorac Surg 1998;65:198-202   DOI   ScienceOn
10 Shim YS. Recent advances in diffuse interstitial lung disease. Tuberc Respir Dis 1989;36:193-207
11 Flabouris A, Myburgh J. The utility of open lung biopsy in patients requiring mechanical ventilation. Chest 1999;115:811-7   DOI   ScienceOn
12 Wilcox AG. Advances in radiology for interstitial lung disease. Curr Opin Pulm Med 1999;5:278-83   DOI
13 Raghu G, Mageto YN, Lockhart D, Schmidt RA, Wood DE, Godwin JD. The accuracy of the clinical diagnosis of new-onset idiopathic pulmonary fibrosis and other interstitial lung disease: a prospective study. Chest 1999;116:1168-74   DOI   ScienceOn
14 Hunninghake GW, Lynch DA, Galvin JR, Gross BH, Muller N, Schwartz DA, et al. Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia. Chest 2003;124:1215-23   DOI   ScienceOn
15 Warner DO, Warner MA, Divertie MB. Open lung biopsy in patients with diffuse pulmonary infiltrates and acute respiratory failure. Am Rev Respir Dis 1988;137:90-4   DOI   ScienceOn
16 Raghu G. Interstitial lung disease: a diagnostic approach. Are CT scan and lung biopsy indicated in every patient? Am J Respir Crit Care Med 1995;151:909-14   DOI   ScienceOn
17 American Thoracic Society, European Respiratory Society. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias: This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002;165:277-304   DOI   ScienceOn
18 Ferson PF, Landreneau RJ, Dowling RD, Hazelrigg SR, Ritter P, Nunchuck S, et al. Comparison of open versus thoracoscopic lung biopsy for diffuse infiltrative pulmonary disease. J Thorac Cardiovasc Surg 1993;106:194-9