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Relations between Polymorphism of NRAMP1 Gene and Susceptibility to Pulmonary Tuberculosis  

Lee, Ji Seok (Department of Internal Medicine, College of Medicine, Pusan National University)
Cho, Jin Hoon (Department of Internal Medicine, College of Medicine, Pusan National University)
Kim, Ki Uk (Department of Internal Medicine, College of Medicine, Pusan National University)
Park, Hye-Kyung (Department of Internal Medicine, College of Medicine, Pusan National University)
Kim, Yun Seong (Department of Internal Medicine, College of Medicine, Pusan National University)
Lee, Ho Seok (Department of Thoracic Surgery, College of Medicine, Pusan National University)
Kim, Yeong Dae (Department of Thoracic Surgery, College of Medicine, Pusan National University)
Jeon, Doo Soo (Masan National Hospital)
Park, Seung Kyu (Masan National Hospital)
Lee, Min Ki (Department of Internal Medicine, College of Medicine, Pusan National University)
Park, Soon Kew (Department of Internal Medicine, College of Medicine, Pusan National University)
Publication Information
Tuberculosis and Respiratory Diseases / v.62, no.6, 2007 , pp. 492-498 More about this Journal
Abstract
Background: Several lines of evidence suggest that a host's genetic factors influence the outcome of exposure to Mycobacterium tuberculosis. The aim of this study was to determine whether polymorphism in NRAMP1 (natural resistance associated macrophage protein 1) gene is associated with the susceptibility or resistance to tuberculosis infection for patients with drug-sensitive pulmonary tuberculosis (DS-TB) and multi-drug resistant pulmonary tuberculosis (MDR-TB). Methods: Eight genetic polymorphisms of the NRAMP1 gene were investigated in patients suffering with DS-TB (n=100) or MDR-TB (n=102), and in healthy normal controls (NC, n=96). The genetic polymorphisms of NRAMP1 were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The frequency of D543N A/G heterogygotes was significantly higher in the DS-TB subjects than the NCs (OR=2.10, 95% CI: 1.00 to 4.41, p=0.049). The frequency of 823C/T T/C heterozygotes was significantly higher in the DS-TB subjects (OR=2.79, 95% CI: 1.11 to 7.04, p=0.029) and the MDR-TB subject (OR=3.30, 95% CI 1.33 to 8.18, p=0.010) than in the NCs. However, the frequency of these genotypes was not different between the DS-TB and MDR-TB subjects. Conclusion: A significant association was found between NRAMP1 823 C/T polymorphism and pulmonary tuberculosis. This result suggests that NRAMP1 polymorphism may be involved in the development of pulmonary tuberculosis in Koreans.
Keywords
NRAMP1; Polymorphism; Tuberculosis;
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