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Cognitive Dysfunction in non-hypoxemic COPD Patients  

Kim, Woo Jin (Department of Internal Medicine, College of Medicine, Kangwon National University)
Han, Seon-Sook (Department of Internal Medicine, College of Medicine, Kangwon National University)
Park, Myoung-Ok (Department of Internal Medicine, College of Medicine, Kangwon National University)
Lee, Seung-Joon (Department of Internal Medicine, College of Medicine, Kangwon National University)
Kim, Seong Jae (Department of Psychiatry, College of Medicine, Kangwon National University)
Lee, Jung Hie (Department of Psychiatry, College of Medicine, Kangwon National University)
Publication Information
Tuberculosis and Respiratory Diseases / v.62, no.5, 2007 , pp. 382-388 More about this Journal
Abstract
Background: The cognitive function is impaired in patients with hypoxemic chronic obstructive pulmonary disease (COPD). However, there are conflicting results regarding the cognitive function in patients with non-hypoxemic COPD. COPD patients also have sleep disorders. This study examined the cognitive function in non-hypoxemic COPD patients, and nocturnal sleep was assessed in COPD patients with a cognitive dysfunction. Methods: Twenty-eight COPD patients (mean age, 70.7 years) with an oxygen saturation > 90%, and 33 healthy control subjects (mean age, 69.5 years) who had visited for a routine check-up were selected. The neurocognitive tests were performed using the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K) Neuropsychological Battery. Results: The scores of the word list recall test (p=0.03) and the word list recognition test (p=0.006) in the COPD group were significantly lower than those in the control group. Nine patients showed a significantly impaired cognitive function. Seven of these underwent polysomnography, which revealed apnea-hypopnea indices ${\geq}$ five per hour in five patients. The median oxygen desaturation index and median limb movement index were 3.6/h and 38.6/h, respectively. Conclusion: These results suggest that the verbal memory function is impaired in non-hypoxemic COPD patients. Six out of seven COPD patients with an impaired cognitive function had sleep disorders of sleep apnea and/or periodic limb movements during sleep.
Keywords
Chronic obstructive pulmonary disease; Cognitive function; Sleep disorders;
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