Browse > Article

Soluble Triggering Receptor Expressed on Myeloid cells-1: Role in the Diagnosis of Pleural Effusions  

Kim, Jung-Hyun (Departments of Internal Medicine, College of Medicine, Pochon CHA University)
Park, Eun-Young (Asan Life Science Institute, Asan Medical Center)
Kim, Won-Hee (Departments of Internal Medicine, College of Medicine, Pochon CHA University)
Park, Woong (Departments of Internal Medicine, College of Medicine, Pochon CHA University)
Jeong, Hye-Cheol (Departments of Internal Medicine, College of Medicine, Pochon CHA University)
Lee, Ji-Hyun (Departments of Internal Medicine, College of Medicine, Pochon CHA University)
Kim, Eun-Kyung (Departments of Internal Medicine, College of Medicine, Pochon CHA University)
Publication Information
Tuberculosis and Respiratory Diseases / v.62, no.4, 2007 , pp. 290-298 More about this Journal
Abstract
Background: The currently available diagnostic markers for pleural effusion have a limited role. The soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is a molecule recently reported to play an important role in the myeloid cell mediated inflammatory response, and is up regulated in the body fluid by bacterial or fungal products. This study examined the expression of sTREM-1 in pleural effusion. Methods: Between April 2004 and December 2005, 48 patients with pleural effusions were enrolled in this study. The pleural fluids were taken and analyzed for the total protein, glucose, lactate dehydrogenase (LDH), adenosine deaminase (ADA), and sTREM-1. Bacterial cultures and cytology tests were also performed. Results: The clinical diagnoses were 17 parapneumonic, 14 tuberculous, and 13 malignant effusions. Four patients presented with transudates. The mean ages of the parapneumonic, tuberculous and malignant effusion groups were $57.1{\pm}19.7$, $49.5{\pm}18.6$, $66.9{\pm}15.5$, and $76.0{\pm}18.1$. respectively. The level of sTREM-1 expression was significantly higher in the parapneumonic effusions ($344.0{\pm}488.7$) than in the tuberculous effusions ($81.7{\pm}56.6$) and malignant effusions ($39.3{\pm}19.6$). With a cut-off value of 55.4pg/ml, the sensitivity and specificity for a parapneumonic effusion was 70.6% and 74.1%. Conclusion: sTREM-1 expression is significantly higher in parapneumonic effusions, suggesting its potential role as an additional diagnostic marker for pleural effusions.
Keywords
Triggering receptor expressed on myeloid cells; Pleural effusion; Differential diagnosis;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By SCOPUS : 4
연도 인용수 순위
1 Grove CS, Lee YC. Vascular endothelial growth factor: the key mediator in pleural effusion formation. Curr Opin Pulm Med 2002;8:294-301   DOI
2 Richeldi L, Mariani M, Losi M, Maselli F, Corbetta L, Buonsanti C, et al. Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections. Eur Respir J 2004;24:247-50   DOI   ScienceOn
3 Gibot S, Kolopp-Sarda MN, Bene MC, Cravoisy A, Levy B, Faure GC, et al. Plasma level of a triggering receptor expressed on myeloid cells-1: its diagnostic accuracy in patients with suspected sepsis. Ann Intern Med 2004;141:9-15   DOI
4 Gibot S, Le Renard PE, Bollaert PE, Kolopp-Sarda MN, Bene MC, Faure GC, et al. Surface triggering receptor expressed on myeloid cells 1 expression patterns in septic shock. Intensive Care Med 2005; 31:594-7   DOI   ScienceOn
5 Bleharski JR, Kiessler V, Buonsanti C, Sieling PA, Stenger S, Colonna M, et al. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol 2003;170:3812-8   DOI
6 Shin MK, Ham HS, Lee WD, Cho YJ, Jeong YY, Kim HC, et al. The diagnostic usefulness of pleural fluid adenosine deaminase with lymphocyte/neutrophil ratio in tuberculous pleural effusion. Tuberc Respir Dis 2004;57:132-7   DOI
7 Hamm H, Light RW. Parapneumonic effusion and empyema. Eur Respir J 1997;10:1150-6   DOI   ScienceOn
8 Gibot S, Massin F, Le Renard P, Bene MC, Faure GC, Bollaert PE, et al. Surface and soluble triggering receptor expressed on myeloid cells-1: expression patterns in murine sepsis. Crit Care Med 2005; 33:1787-93   DOI   ScienceOn
9 Gibot S, Cravoisy A, Levy B, Bene MC, Faure G, Bollaert PE. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med 2004;350:451-8   DOI   ScienceOn
10 Brown LF, Detmar M, Claffey K, Nagy JA, Feng D, Dvorak AM, et al. Vascular permeability factor/ vascular endothelial growth factor: a multifunctional angiogenic cytokine. EXS 1997;79:233-69
11 Light RW, Macgregor MI, Luchsinger PC, Ball WC Jr. Pleural effusion: the diagnostic separation of transudates and exudates. Ann Intern Med 1972;77:507-13   DOI   ScienceOn
12 Marel M. Zrustova M. Stasny B. Light RW. The incidence of pleural effusion in a well-defined region. Epidemiologic study in central Bohemia. Chest 1993; 104:1486-9   DOI   ScienceOn
13 Light RW, Girard WM, Jenkinson SG, George RB. Parapneumonic effusions. Am J Med 1980;69:507-12   DOI   ScienceOn
14 Romero S, Fernandez C, Arriero JM, Espasa A, Candela A, Martin C, et al. CEA, CA 15-3 and CYFRA 21-1 in serum and pleural fluid of patients with pleural effusions. Eur Respir J 1996;9:17-23
15 Mackiewicz A, Speroff T, Ganapathi MK, Kushner I. Effect of cytokine combinations on acute phase protein production in two human hepatoma cell lines. J Immunol 1991;146:3032-7
16 Phua J, Koay ES, Zhang D, Tai LK, Boo XL, Lim KC, et al. Soluble triggering receptor expressed on myeloid cells-1 in acute respiratory infections. Eur Respir J 2006;28:695-702   DOI   ScienceOn
17 Valdes L, San Jose E, Alvarez D, Sarandeses A, Pose A, Chomon B, et al. Diagnosis of tuberculous pleurisy using the biologic parameters adenosine deaminase, lysozyme, and interferon gamma. Chest 1993;103: 458-65   DOI   ScienceOn
18 Kim SH, Lee WY, Park JY, Park HS, Han HK, Ju HS, et al. Diagnostic value of C-reactive protein and vascular endothelial growth factor in differentiation of pleural effusions. Tuberc Respir Dis 2003;55:467-77   DOI
19 Light RW. Pleural diseases. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2001
20 Romero-Candeira S, Hernandez L, Romero-Brufao S, Orts D, Fernandez C, Martin C. Is it meaningful to use biochemical parameters to discriminate between transudative and exudative pleural effusions? Chest 2002;122:1524-9   DOI   ScienceOn
21 Maskell NA, Butland RJ. BTS guidelines for the investigation of a unilateral pleural effusion in adults. Thorax 2003;58 Suppl 2:ii8-17   DOI
22 Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999;340:448-54   DOI   ScienceOn
23 Gibot S, Cravoisy A, Kolopp-Sarda MN, Bene MC, Faure G, Bollaert PE, et al. Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis. Crit Care Med 2005; 33:792-6   DOI   ScienceOn
24 Rahman NM, Chapman SJ, Davies RJ. The approach to the patient with a parapneumonic effusion. Clin Chest Med 2006;27:253-66   DOI   ScienceOn
25 Villena V, Lopez-Encuentra A, Echave-Sustaeta J, Martin-Escribano P, Ortuno-de-Solo B, Estenoz-Alfaro J. Diagnostic value of CA 72-4, carcinoembryonic antigen, CA 15-3, and CA 19-9 assay in pleural fluid. A study of 207 patients. Cancer 1996;78:736-40   DOI   ScienceOn
26 Bouchon A, Dietrich J, Colonna M. Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 2000;164:4991-5   DOI
27 Bouchon A, Facchetti F, Weigand MA, Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001;410:1103-7   DOI   ScienceOn
28 Meisner M. Biomarkers of sepsis: clinically useful? Curr Opin Crit Care 2005;11:473-80   DOI   ScienceOn