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Clinical implication of Dendritic Cell Infiltration in Cervical Tuberculous Lymphadenitis  

Jung, Jae Woo (Department of Internal Medicine, College of Medicine, Chung-Ang University)
Lee, Young Woo (Department of Internal Medicine, College of Medicine, Chung-Ang University)
Choi, Jae Cheol (Department of Internal Medicine, College of Medicine, Chung-Ang University)
Yoo, Seung Min (Dept. of Radiology, College of Medicine, Chung-Ang University)
Lee, Hwa Yeon (Dept. of Radiology, College of Medicine, Chung-Ang University)
Lim, Seoung Young (Department of Internal Medicine, Kangbuk Samsung Hospital, Sung Kyun Kwan University, School of Medicine)
Shin, Jong Wook (Department of Internal Medicine, College of Medicine, Chung-Ang University)
Kim, Jae Yoel (Department of Internal Medicine, College of Medicine, Chung-Ang University)
Park, In Whn (Department of Internal Medicine, College of Medicine, Chung-Ang University)
Kim, Mi Kyung (Dept. of Pathology, College of Medicine, Chung-Ang University)
Choi, Byoung Whui (Department of Internal Medicine, College of Medicine, Chung-Ang University)
Publication Information
Tuberculosis and Respiratory Diseases / v.60, no.5, 2006 , pp. 523-531 More about this Journal
Abstract
Background : Cervical tuberculous lymphadenopathy is a very common disease with a similar incidence to pulmonary tuberculosis. Dendritic cells play a role of initial antigen presentation of this illness. Nevertheless, the precise role of these antigen-presenting cells according to the clinical features in unclear. The aim of this study was to determine the clinical implication of dendritic cell infiltration in the cervical lymph nodes. Methods : A review of the clinical characteristics was carried out retrospectively based on the clinical records and radiography. Immunohistochemical staining was performed on the available histology specimens of 72 cases using the S-100b polyclonal antibody for dendritic cells. The number of dendritic cells with tuberculous granuloma were determined. A $X^2$ test, unpaired T test and multiple logistic regression analysis were performed. Results : Thirty percent of subjects had previous or concurrent pulmonary TB. Twenty one percent of cases showed a positive reaction on the AFB stain. Within a granuloma, the number of infiltrated dendritic cells was $113.0{\pm}7.0$. The incidence of fever and cough decreased with increasing infiltration of dendritic cells Multivariate regression analysis showed that the infiltration of dendritic cells could significantly contribute to fever. Conclusion : Overall, dendritic cells can control a Mycobacterium tuberculosis infection and modulate the immune response, as well as resolve the clinical manifestations of TB lymphadenopathy.
Keywords
Tuberculosis; Lymph Node; S-100b; Dendritic Cells;
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