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Benign Metastasizing Pulmonary Leiomyoma with Hemoptysis  

Park, So Young (Department of Internal Medicine, College of Medicine, Hallym University)
Lim, Eun Ju (Department of Internal Medicine, College of Medicine, Hallym University)
Jang, Ji-Sun (Department of Internal Medicine, College of Medicine, Hallym University)
Kim, Chang-Hwan (Department of Internal Medicine, College of Medicine, Hallym University)
Jee, Hyun Keun (Department of Thoracic surgery, College of Medicine, Hallym University)
Cho, Sung Jin (Department of Anatomical Pathology, College of Medicine, Hallym University)
Park, Yong Bum (Department of Internal Medicine, College of Medicine, Hallym University)
Lee, Jae Young (Department of Internal Medicine, College of Medicine, Hallym University)
Mo, Eun Kyung (Department of Internal Medicine, College of Medicine, Hallym University)
Publication Information
Tuberculosis and Respiratory Diseases / v.60, no.1, 2006 , pp. 92-96 More about this Journal
Abstract
A benign metastasizing pulmonary leiomyoma(BMPL) is a rare disease that is usually detected years after a hysterectomy or myomectomy. Despite the benign pathological appearance, these tumors can metastasize and become clinically malignant. Recently, we experienced case of BMPL with hemoptysis. A 43-year-old woman, who had undergone a hysterectomy due to uterine leiomyoma 8 years ago, visited our department complaining of intermittent hemoptysis. A chest CT showed bilateral multiple nodular lesions. Video-associated thoracoscopy was performed. The resected small nodular lesion revealed the proliferation of spindle cells without mitosis or nuclear atypism. The lesions tested positive to the smooth muscle marker (actin) by immunohistochemical staining. Therefore, the multiple nodules were considered as benign metastasizing pulmonary leiomyoma from a uterine leiomyoma. GnRH analogue therapy was initiated. A chest CT showed that the size and number of pulmonary lesions did not change after 3 months, and the patient was symptom free.
Keywords
Benign metastasizing pulmonary leiomyoma; Uterine leiomyoma; GnRH analogue;
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