Browse > Article

Pulmonary Fibrosis Under Chemotherapy with Oxaliplatin, 5-fluorouracil, and Leucovorin  

Jung, Jin Yong (Department of Internal Medicine, College of Medicine, Korea University)
Hur, Gyu Young (Department of Internal Medicine, College of Medicine, Korea University)
Jung, Ki Hwan (Department of Internal Medicine, College of Medicine, Korea University)
Jung, Hae Chul (Department of Internal Medicine, College of Medicine, Korea University)
Lee, Sung Yong (Department of Internal Medicine, College of Medicine, Korea University)
Choi, In Keun (Department of Internal Medicine, College of Medicine, Korea University)
Lee, Sang Yeub (Department of Internal Medicine, College of Medicine, Korea University)
Kim, Je Hyeong (Department of Internal Medicine, College of Medicine, Korea University)
Seo, Jae Hong (Department of Internal Medicine, College of Medicine, Korea University)
Shin, Chol (Department of Internal Medicine, College of Medicine, Korea University)
Shim, Jae Jeong (Department of Internal Medicine, College of Medicine, Korea University)
In, Kwang Ho (Department of Internal Medicine, College of Medicine, Korea University)
Kang, Kyung Ho (Department of Internal Medicine, College of Medicine, Korea University)
Yoo, Se Hwa (Department of Internal Medicine, College of Medicine, Korea University)
Publication Information
Tuberculosis and Respiratory Diseases / v.59, no.5, 2005 , pp. 536-540 More about this Journal
Abstract
The combination of oxaliplatin, 5-fluorouracil and leucovorin (FOLFOX) has recently been shown to be beneficial in advanced colorectal and gastric cancers. The side effects of this regimen include neutropenia, diarrhea and neurosensory toxicity. However, case reports on the pulmonary toxicities of this regimen are very limited. Especially, the development of pulmonary fibrosis has never been cited in the literature. Herein is reported the case of a patient treated with oxaliplatin, 5-fluorouracil and leucovorin combination chemotherapy in whom pulmonary fibrosis developed, but which improved after steroid pulse therapy.
Keywords
Oxaliplatin; Fluorouracil; Leucovorin; Chemotherapy; Pulmonary fibrosis;
Citations & Related Records

Times Cited By SCOPUS : 1
연도 인용수 순위
1 Bleiberg H, de Gramont A. Oxaliplatin plus 5-fluorouracil: clinical experience in patients with advanced colorectal cancer. Semin Oncol 1998;25:32-9
2 Brandi G, Pantaleo MA, Galli C, Falcone A, Antonuzzo A, Mordenti P, et al. Hypersensitivity reactions related to oxaliplatin (OHP). Br J Cancer 2003;89:477- 81   DOI   ScienceOn
3 Fielding JW, Crocker J, Stockley RA, Brookes VS. Interstitial fibrosis in a patient treated with 5-fluorouracil and mitomycin C. Br Med J 1979;2:551-2
4 Raymond E, Faivre S, Woynarowski JM, Chaney SG. Oxaliplatin: mechanism of action and antineoplastic activity. Semin Oncol 1998;25:4-12
5 American Thoracic Society/European Respiratory Society. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias: this joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002;165:277-304.   DOI   ScienceOn
6 de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000;18:2938-47   DOI
7 Fielding JW, Stockley RA, Brookes VS. Interstitial lung disease in a patient treated with 5-fluorouracil and mitomycin C. Br Med J 1978;2:602
8 Grothey A. Oxaliplatin-safety profile: neurotoxicity. Semin Oncol 2003;30:5-13
9 Trisolini R, Lazzari Agli L, Tassinari D, Rondelli D, Cancellieri A, Patelli M, et al. Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy. Eur Respir J 2001;18:243-5
10 Gagnadoux F, Roiron C, Carrie E, Monnier-Cholley L, Lebeau B. Eosinophilic lung disease under chemotherapy with oxaliplatin for colorectal cancer. Am J Clin Oncol 2002;25:388-90   DOI   ScienceOn
11 Webb WR, Mueller NL, Naidich DP. High-resolution CT of the lung. 3rd ed. Philadelphia: Lippincot Williams & Wilkins; 2001
12 Louvet C, Andre T, Tigaud JM, Gamelin E, Douillard JY, Brunet R, et al. Phase II study of oxaliplatin, fluorouracil, and folinic acid in locally advanced or metastatic gastric cancer patients. J Clin Oncol 2002; 20:4543-8   DOI   ScienceOn
13 Cassidy J, Misset JL. Oxaliplatin-related side effects: characteristics and management. Semin Oncol 2002; 29:11-20   DOI