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The Role of Respiratory Viral Infections in Exacerbation of Asthma and Chronic Obstructive Pulmonary Disease (COPD)  

Yoo, Ji Youn (Department of Internal medicine, Hallym University College of Medicine)
Kim, Dong-Gyu (Department of Internal medicine, Hallym University College of Medicine)
Eom, Kwang-Seok (Department of Internal medicine, Hallym University College of Medicine)
Shin, Taerim (Department of Internal medicine, Hallym University College of Medicine)
Park, Yong Bum (Department of Internal medicine, Hallym University College of Medicine)
Lee, Jae Young (Department of Internal medicine, Hallym University College of Medicine)
Jang, Seung Hun (Department of Internal medicine, Hallym University College of Medicine)
Bahn, Joon-Wo (Department of Internal medicine, Hallym University College of Medicine)
Kim, Cheol Hong (Department of Internal medicine, Hallym University College of Medicine)
Park, Sang Myeon (Department of Internal medicine, Hallym University College of Medicine)
Lee, Myung Goo (Department of Internal medicine, Hallym University College of Medicine)
Hyun, In-Gyu (Department of Internal medicine, Hallym University College of Medicine)
Lee, Kyu Man (Department of Pathology, Hallym University College of Medicine)
Jung, Ki-Suck (Department of Internal medicine, Hallym University College of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.59, no.5, 2005 , pp. 497-503 More about this Journal
Abstract
Backgrounds : The exacerbations of asthma and chronic obstructive pulmonary disease (COPD) have been suggested to be associated with respiratory tract viral infections (RTVIs). However, the rates of virus detection in previous studies have been quite variable, with lower rates for the exacerbation of COPD. Therefore, the virus detection of patients with exacerbation of asthma and COPD were investigated. Methods : 20 and 24 patients with exacerbation of asthma and COPD, respectively, were enrolled. Nasal and sputum samples were taken, and polymerase chain reaction (PCR) for rhinovirus and coronavirus and virus culture for influenza A, B, RSV and parainfluenza virus performed. Results : The mean $FEV_1/FVC$ in the exacerbation of asthma and COPD patients were 1.9/2.9 L (65.5%) and 1.1/2.6 L (42.3%), respectively. Respiratory virus was detected in 13 (65%) patients with exacerbation of asthma and rhinovirus was detected in 9. Coronavirus, influenza A, RSV and parainfluenza virus were detected in 2, 2, 1 and 1 patients with asthma. Among patients with exacerbation of COPD, a virus was detected in 14 (58.3%) patients, with rhinovirus, coronavirus and influenza A detected in 10, 3 and 4, respectively. Conclusions : This study suggested that RTVIs may have a role in the exacerbation of COPD as well as asthma.
Keywords
Asthma; Chronic obstructive pulmonary Disease (COPD); Exacerbation; Viral infection;
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