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Isolated Volume Response to a Bronchodilator and GOLD Classification in Patients with COPD  

Hur, Gyu Young (Department of Internal Medicine, Korea University Medical Center)
Lee, Seung Hyeun (Department of Internal Medicine, Korea University Medical Center)
Jung, Jin Yong (Department of Internal Medicine, Korea University Medical Center)
Kim, Se Joong (Department of Internal Medicine, Korea University Medical Center)
Lee, Kyoung Ju (Department of Internal Medicine, Korea University Medical Center)
Lee, Eun Joo (Department of Internal Medicine, Korea University Medical Center)
Jung, Hye Cheol (Department of Internal Medicine, Korea University Medical Center)
Lee, Sung Yong (Department of Internal Medicine, Korea University Medical Center)
Lee, Sang Yeub (Department of Internal Medicine, Korea University Medical Center)
Kim, Je Hyeung (Department of Internal Medicine, Korea University Medical Center)
Shin, Chol (Department of Internal Medicine, Korea University Medical Center)
Shim, Jae Jeong (Department of Internal Medicine, Korea University Medical Center)
In, Kwang Ho (Department of Internal Medicine, Korea University Medical Center)
Kang, Kyung-Ho (Department of Internal Medicine, Korea University Medical Center)
Yoo, Se Hwa (Department of Internal Medicine, Korea University Medical Center)
Publication Information
Tuberculosis and Respiratory Diseases / v.59, no.1, 2005 , pp. 23-29 More about this Journal
Abstract
Background : Chronic obstructive lung disease is characterized by smoke-related, gradually progressive, fixed airflow obstructions. However, some studies suggested that a reversible bronchial obstruction is common in chronic obstructive lung disease. Such reversibility persists despite the continued treatment with aerosolized bronchodilators and it appears to be related to the diminution in symptoms. The isolated volume response to a bronchodilator is defined as a remarkable increase in the FVC in response to the administration of a bronchodilator whereas the $FEV_1$ remains unchanged. This has been suggested in patients with severe emphysema. Therefore, the aim of this study was to determine the relationship between the response to a bronchodilator and the severity of an airflow obstruction in COPD patients using the GOLD classification. Methods : This study examined 124 patients with an airway obstruction. The patients underwent spirometry, and the severity of the airflow obstruction was classified by GOLD. The response groups were categorized by an improvement in the FVC or $FEV_1$ > 12%, and each group was analyzed. Results : Most subjects were men with a mean age of $65.9{\pm}8.5$ years. The mean smoking history was $41.26{\pm}20.1$ pack years. The isolated volume response group had relatively low $FEV_1$ and FVC values compared with the other groups. (p<0.001) Conclusion : In this study, an isolated volume response to a bronchodilator is a characteristic of a severe airway obstruction, which is observed in patient with a relatively poorer baseline lung function.
Keywords
COPD; Bronchodilator; GOLD; Isolated volume response;
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