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Recovery Rate and Characteristics of Nontuberculous Mycobacterial Isolates in a University Hospital in Korea  

Lee, Jung Yeon (Division of Pulmonary and Critical Care Medicine University of Ulsan College of Medicine, Asan Medical Center)
Choi, Hee Jin (University of Ulsan College of Medicine, Asan Medical Center, Asan Institute for Life Sciences)
Lee, Hyeyoung (Department of Biomedical Laboratory Science, Yonsei University Wonju College of Medicine)
Joung, Eun Young (Product Planning and Development Dept. M&D Co., LTD.)
Huh, Jin Won (Division of Pulmonary and Critical Care Medicine University of Ulsan College of Medicine, Asan Medical Center)
Oh, Yeon-Mok (Division of Pulmonary and Critical Care Medicine University of Ulsan College of Medicine, Asan Medical Center)
Lee, Sang Do (Division of Pulmonary and Critical Care Medicine University of Ulsan College of Medicine, Asan Medical Center)
Kim, Woo Sung (Division of Pulmonary and Critical Care Medicine University of Ulsan College of Medicine, Asan Medical Center)
Kim, Dong Soon (Division of Pulmonary and Critical Care Medicine University of Ulsan College of Medicine, Asan Medical Center)
Kim, Won Dong (Division of Pulmonary and Critical Care Medicine University of Ulsan College of Medicine, Asan Medical Center)
Shim, Tae Sun (Division of Pulmonary and Critical Care Medicine University of Ulsan College of Medicine, Asan Medical Center)
Publication Information
Tuberculosis and Respiratory Diseases / v.58, no.4, 2005 , pp. 385-391 More about this Journal
Abstract
Background : The incidence of nontuberculous mycobacterium (NTM) infections in Korea is increasing. This retrospective study was performed to examine the recovery rate of NTM from respiratory specimens as well as the isolated NTM colony characteristics, and to assess the clinical significance of a NTM isolation. Methods : The results of the respiratory specimens requested for an acid-fast bacilli (AFB) examination during 2002 at Asan Medical Center, along with the patients clinical characteristics were analyzed. Results : A total 26,820 respiratory specimens were requested for the acid-fast bacilli (AFB) smear and culture during the study period. The proportion of M. tuberculosis and NTM isolation was 5.7% and 2.2%, respectively. Among the AFB smear and culture positive specimens, 12.2% were found to be NTM. The scotochromogen showing a low colony count < 20, which appeared to be contaminants, were isolated in 31.8% of the 584 NTM isolates. Excluding the low-colony scotochromogens, the M. avium-intracellulare complex was the most common NTM isolates (42.1%), and was also the most common causative organism for NTM pulmonary diseases. 8.4% (23/275) and 17.8% (49/275) of patients with NTM isolates met the American and British Thoracic Society diagnostic criteria for NTM pulmonary disease, respectively. Conclusion : In case of a positive AFB-smear or culture result, the possibility of NTM being a causative organism should always be considered, even in Korea, which has an intermediate incidence of tuberculosis.
Keywords
Acid-fast bacilli; Colony; Nontuberculous mycobacterium; Respiratory specimen;
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1 Prince DS, Peterson DD, Steiner RM, Gottlieb JE, Scott R, Israel HL, et al. InfectionwithMycobacterium avium complex in patients without predisposing conditions. N Engl J Med 1989;321:863-8   DOI   ScienceOn
2 Koh WJ, Kwon OJ, Ham HS, Suh GY, Chung MP, Kim H, et al. Clinical significance of nontuberculous mycobacteria isolated from respiratory specimens. Korean J Med 2003;65:10-21
3 Hosker HS, Lam CW, Ng TK, Ma HK, Chan SL. The prevalence and clinical significance of pulmonary infection due to non-tuberculous mycobacteria in Hong Kong. Respir Med 1995;89:3-8
4 KohWJ, Kwon OJ, Yu CM, Jeon KM, Suh GY, Chung MP, et al. Recovery rate of nontuberculous mycobacteria fromacid-fast-bacilli smear positive sputumspecimens. Tuberc Respir Dis 2003;54:22-32   DOI
5 Lew WJ, Ahn DI, Yoon YJ, Cho JS, Kwon DW, Kim SJ, et al. Clinical experience on mycobacterial diseases other than tuberculosis. Tuberc Respir Dis 1992;39:425-32
6 Ringuet H, Akoua-Koffi C, Honore S, Varnerot A, Vincent V, Berche P, et al. Hsp65 sequencing for identification of rapidly growing mycobacteria. J Clin Microbiol 1999;37:852-7
7 British Thoracic Society. Management of opportunist mycobacterial infections: Joint tuberculosis committee guidelines 1999. Thorax 2000;55:210-8   DOI   PUBMED   ScienceOn
8 Good RC, Snider DE Jr. Isolation of nontuberculous mycobacteria in the United States, 1980. J Infect Dis 1982;146:829-33   DOI   ScienceOn
9 Marras TK, Daley CL. Epidemiology of human pulmonary infection with nontuberculous mycobacteria. Clin Chest Med 2002;23:553-67   DOI   ScienceOn
10 Aberg JA, Yajko DM, Jacobson MA. Eradication of AIDS-related disseminated Mycobacterium avium complex infection after 12 months of antimycobac-terial therapy combined with highly active antiretr-oviral therapy. J Infect Dis 1998;178:1446-9   DOI   ScienceOn
11 Tenover FC, Crawford JT, Huebner RE, Geiter LJ, Horsburgh CR Jr, Good RC. The resurgence of tuberculosis: is your laboratory ready? J Clin Microbiol 1993;31:767-70
12 American Thoracic Society. Diagnostic standards and classification of tuberculosis. Am Rev Respir Dis 1990;142:725-35   DOI   ScienceOn
13 Lamden K, Watson JM, Knerer G, Ryan MJ, Jenkins PA. Opportunist mycobacteria in England and Wales:1982 to 1994. Commun Dis Rep CDR Rev 1996;6:R 147-51
14 Patel JB, Leonard DG, Pan X, Musser JM, Berman RE, Nachamkin I. Sequence-based identification of mycobacterium species using the MicroSeq 500 16S rDNA bacterial identification system. J Clin Microbiol 2000;38:246-51
15 American Thoracic Society. Diagnosis and treatment of disease caused by nontuberculous mycobacteria. Am J Respir Crit Care Med 1997;156:S1-25   DOI   ScienceOn
16 Falkinham JO 3rd. Epidemiology of infection by non-tuberculous mycobacteria. Clin Microbiol Rev 1996;9:177-215
17 Devallois A, Goh KS, Rastogi N. Rapid identification of mycobacteria to species level by PCR-restriction fragment length polymorphism analysis of the hsp65 gene and proposition of an algorithm to differentiate 34 mycobacterial species. J Clin Microbiol 1997;35:2969-73
18 Sakatani M. Nontuberculous mycobacteriosis: the present status of epidemiology and clinical studies. Kekkaku 1999;74:377-84
19 Scientific Committee in Korean Academy of Tuberculosis and Respiratory Diseases. National survey of mycobacterial diseases other than tuberculosis in Korea. Tuberc Respir Dis 1995;42:277-94   DOI
20 O'Brien RJ, Geiter LJ, Snider DE Jr. The epidemiology of nontuberculous mycobacterial diseases in the United States: results from a national survey. Am Rev Respir Dis 1987;135:1007-14