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Nuclear Factor-κB(NF-κB) Activity and Levels of IL-6, IL-8 and TNF-α in Induced Sputum in the Exacerbation and Recovery of COPD Patients  

Song, So Hyang (Department of Internal Medicine, The Catholic University of Korea)
Kim, Chi Hong (Department of Internal Medicine, The Catholic University of Korea)
Kwon, Soon Seog (Department of Internal Medicine, The Catholic University of Korea)
Kim, Young Kyoon (Department of Internal Medicine, The Catholic University of Korea)
Kim, Kwan Hyoung (Department of Internal Medicine, The Catholic University of Korea)
Moon, Hwa Sik (Department of Internal Medicine, The Catholic University of Korea)
Song, Jeong Sup (Department of Internal Medicine, The Catholic University of Korea)
Park, Sung Hak (Department of Internal Medicine, The Catholic University of Korea)
Publication Information
Tuberculosis and Respiratory Diseases / v.58, no.2, 2005 , pp. 152-159 More about this Journal
Abstract
Background : Exacerbations of chronic obstructive pulmonary disease (COPD) are thought to be associated with increased airway inflammation, and the $NF-{\kappa}B$ is known to be an indicator of cellular activation and of inflammatory mediator production. This study was undertaken to investigate the change of cytokine characteristics and $NF-{\kappa}B$ activity in induced sputum of COPD patients during exacerbation and recovery of the disease. Methods : Sputum induction was performed in 37 patients with COPD during exacerbation and during recovery and in 15 healthy subjects. Cell counts, levels of IL-6, IL-8 and $TNF-{\alpha}$ in induced sputum and NF-kB activity in macrophage of induced sputum were measured. Results : Patients with COPD showed significantly increased levels of IL-6, IL-8 and $TNF-{\alpha}$(p<0.01) and increased $NF-{\kappa}B$ activity in induced sputum(p<0.05) as compared with control subjects. Level of IL-8 during exacerbation of COPD decreased significantly during recovery(p<0.05). $NF-{\kappa}B$ activity and levels of IL-6 and $TNF-{\alpha}$ tended to be decreased during recovery, but not siginificantly. Conclusion : Activation of $NF-{\kappa}B$ and increased levels of IL-6, IL-8 and $TNF-{\alpha}$ were thought to be associated with pathogenesis and exacerbations of COPD.
Keywords
COPD; exacerbation; $NF-{\kappa}B$; IL-6; IL-8; $TNF-{\alpha}$;
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