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The Correlation between Bronchostenosis and Changes in the Levels of Interferon-γ and Transforming Growth Factor-β during the Treatment in patients with Endobronchial Tuberculosis  

Kim, Ki Uk (Department of Internal Medicine, College of Medicine, Pusan National University)
Lee, Su Jin (Department of Internal Medicine, College of Medicine, Pusan National University)
Lee, Jae Hyung (Department of Internal Medicine, College of Medicine, Pusan National University)
Cho, Woo Hyun (Department of Internal Medicine, College of Medicine, Pusan National University)
Jung, Kyung Sik (Department of Internal Medicine, College of Medicine, Pusan National University)
Joe, Jin Hoon (Department of Internal Medicine, College of Medicine, Pusan National University)
Kim, Yun Seong (Department of Internal Medicine, College of Medicine, Pusan National University)
Lee, Min Ki (Department of Internal Medicine, College of Medicine, Pusan National University)
Kim, Yeong Dae (Department of Thoracic Surgery, College of Medicine, Pusan National University)
Choi, Young Min (Medical Research Institute of Pusan National University Hospital)
Park, Soon Kew (Department of Internal Medicine, College of Medicine, Pusan National University)
Publication Information
Tuberculosis and Respiratory Diseases / v.58, no.1, 2005 , pp. 18-24 More about this Journal
Abstract
Background : Endobronchial tuberculosis often complicates bronchostenosis, which can cause dyspnea due to an airway obstruction, and can be misdiagnosed as bronchial asthma or lung cancer. This study investigated the possible correlation between the $interferon-{\gamma}$($IFN-{\gamma}$) and transforming growth $factor-{\beta}$($TGF-{\beta}$) levels in the serum and bronchial washing fluid and the treatment results in endobronchial tuberculosis patients. Methods : Sixteen patients, who were diagnosed as endobronchial tuberculosis using bronchoscopy, and 10 healthy control subjects were enrolled in this study. The $IFN-{\gamma}$ and $TGF-{\beta}$ levels were measured in the serum and bronchial washing fluid of 16 endobronchial tuberculosis patients before and after treatment using the ELISA method. The endobronchial tuberculosis patients were divided into those who showed bronchial fibrostenosis after treatment and those who did not. Results : The $IFN-{\gamma}$ and $TGF-{\beta}$ levels in the bronchial washing fluid in endobronchial tuberculosis patients were elevated comparing to the control (p<0.05). After treatment, 7 of the 16 endobronchial tuberculosis patients showed bronchial fibrostenosis and the other 9 cases healed without this sequela. In the patients with fibrostenosis after treatment, the initial serum $TGF-{\beta}$ level was lower than the patients without fibrostenosis after treatment (p<0.05). Moreover, the serum $TGF-{\beta}$ level after treatment further decreased comparing to the patients without fibrostenosis after treatment(p<0.05). Conclusion : Elevated $IFN-{\gamma}$ and $TGF-{\beta}$ levels in the bronchial washing fluid in endobronchial tuberculosis patients are believed to be related to the pathogenesis of endobronchial tuberculosis. The decreased initial serum $TGF-{\beta}$ level and the change in the serum $TGF-{\beta}$ level after treatment are believed to be involved in bronchial fibrostenosis during the course of the disease.
Keywords
endobronchial tuberculosis; bronchostenosis; $IFN-{\gamma}$; $TGF-{\beta}$;
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