Browse > Article

A Case of Primary Signet Ring Cell Carcinoma of Lung with Multiple Bone Metastasis  

Shin, Do Hyun (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine)
Kim, Hyoung Il (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine)
Lim, Seon-Kyo (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine)
Lee, Seung Won (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine)
Jung, Youn Mu (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine)
Choi, Young In (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine)
Sheen, Seung Soo (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine)
Park, Joo Hun (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine)
Oh, Yoon Jung (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine)
Park, Kwang Joo (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine)
Hwang, Sung Chul (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine)
Park, Rae Woong (Department of Pathology, Ajou University School of Medicine)
Chul, Shim (Department of Pathology, Ajou University School of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.57, no.6, 2004 , pp. 594-598 More about this Journal
Abstract
Signet ring cell carcinoma of lung is an unique variant of mucin producing adenocarcinoma which is characterized by abundant intracellular mucin accumulation. Only a few cases of primary signet ring cell carcinoma of lung have been reported in the world wide literature. And we have, recently experienced one case of primary signet ring cell carcinoma of lung. A 55 years old man was evaluated for paralysis of lower extremities and was found to have lung cancer in the left upper and lower lobe with pleural, multiple spinal, bone and liver metastases. Signet ring tumor cells were revealed by cytologic examination of pleural fluids. And there were no evidence of signet ring cell carcinoma of other organs. Primary signet ring cell carcinoma of lung seems to have an aggressive behavior and therapeutic modalities could be different from those for signet ring cell carcinomas from other organs. Therefore it is important to separate primary signet ring cell adenocarcinoma of lung from metastatic tumors.
Keywords
Signet ring cell carcinoma; Lung cancer;
Citations & Related Records

Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 Hayashi H, Kitamura H, Nakatani Y, Inayama Y, Ito T. Rrimary signet ring cell carcinoma of the lung: histochemical and immunohistochemical characterization Hum Pathol 1999;30:378-83
2 Kish JK, Ro JY, Ayala AG, Memurtrey MJ. Primary mucinous adenocarcinoma of the lung with signet-ring cells: a histochemical comparion with signet-ring cell carcinomas of other sites. Hum Pathol 1989;20:1097-102
3 Kondo A, Ogisu B, Mitsuya H. Signet-ting cell carcinoma involved the urinary bladder: report of a case and review of 21 eases. Urol Int 1981;36:373-9
4 Frost AR, Terahata S, Yeh T, Siegel RS, Overmoyer B, Silverberg SG. The significance of signet ring cells in infiltrating lobular carcinoma of the breast. Arch Pathol Lab med. 1995;119:64-8
5 Castro CY, Moran CA. Fheder DG, Suster S. Primary slgnet ring cell adenocarcinomas of the lung: a clinicopathologic study of 15 cases. Histopathology. 2001.39:397-401
6 Merchant SH, Amin MB, Tamboli P, Ro J, Ordonez NG, Ayala AG, et al. Primary signet ring cell carcinoma of lung: Immunohistochemical study and comparison with non-pulmonary signet ring cell carcinomas. Am J Surg Pathol 2001;25:1515-9
7 Tung SY, Wu CS, Chen PC, Kuo YC, Chang KY, Wu SS, et al. Primary signet ring cell carcinoma of colorectum: an age-and sex-matched controlled study. Am J Gastroenetrolol 1996;91: 2195-9
8 Kim H, Dorfman RF, Rappaport H. Signet ring cell lymphoma: A rare morphologic and functional expression of nodular (follicular) lymphoma. Am J Surg Pathol. 1978;2:119-32
9 Rosado-de-Christenson ML, Templeton PA, Moran CA. Bronchogenic carcinoma: radiologic-pathologic correlation. Radiographics 1994;14:429-46
10 Ise Y, Yanagawa H, Hirose T, Tani K, Yano S, Suzuki Y, et al. An autopsy ease of cytokeratin 7-positive minute adenocarcinoma of the lung with syatemic metastasis. Intern Med 1998;37:766-9
11 Sarma DP, Hoffmann EO. Primary signet ring cell carcinoma of the lung. Hum Pathol. 1990;21:459-60
12 Choi WI, Sohn JH, Kwon OY, Hur JS, Hwang JS, Han SB, et al. A case of primary signet ring cell carcinoma of the lung. Tuberc Respir Dis 1994:41: 562-67
13 Yamashina M. A variant of early gastric carcinoma: histologic and histochemical studies of early signet ring cell carcinoma discovered beneath preserved surface epithelium. Caner 1986;58:1333-9
14 Hiraki A, Ueoka H, Yoshino T, Tabata M, Kiura K, Taninioto Y, et al. Primary signet ring cell carcinoma of Ihe lung with histochemical characterization. Anticancer Res 2002;22:1079-81