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Primary Signet Ring Cell Carcinoma of the Lung: A Case Report  

Cho, Joo Yeon (Department of Internal Medicine, Inje University, College of Medicine)
Lee, Hyun-Kyung (Department of Internal Medicine, Inje University, College of Medicine)
Lee, Sung Soon (Department of Internal Medicine, Inje University, College of Medicine)
Lee, Young Min (Department of Internal Medicine, Inje University, College of Medicine)
Jin, Jae Yong (Department of Internal Medicine, Inje University, College of Medicine)
Lee, Hyuk Pyo (Department of Internal Medicine, Inje University, College of Medicine)
Kim, Joo In (Department of Internal Medicine, Inje University, College of Medicine)
Choi, Soo Jeon (Department of Internal Medicine, Inje University, College of Medicine)
Kang, Yun Kyung (Department of Pathology, Inje University, College of Medicine)
Ro, Jae Yoon (Department of Pathology, University of Ulsan, College of Medicine, Asan Medical Center)
Yum, Ho-Kee (Department of Internal Medicine, Inje University, College of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.57, no.5, 2004 , pp. 461-464 More about this Journal
Abstract
Signet ring cell carcinoma (SRCC) of the lung is a rare variant of pulmonary adenocarcinoma. Because the majority of SRCCs in the lung are metastatic tumors from stomach, colon, or breast. The differential diagnosis of primary SRCC from metastatic SRCC is important but may be problematic. Recently, immunohistochemical studies are known to be valuable in determining primary sites of SRCC. Herein, we present a case of primary signet ring cell carcinoma of the lung in a 67-year-old man. Even though radiographic findings of our case were more suggestive of metastatic orgin of SRCC in the lung, we could finally conclude that lung was the primary site of SRCC with the help of immunohistochemical studies (positive TTF-1 and CK7, and negative CK 20) and other diagnostic work up.
Keywords
Signet ring cell carcinoma; Lung; TTF-1;
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