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Adjuvant Chemotherapy after Surgical Resection for Small-Cell Carcinoma of Lung  

Kim, Hak-Ryul (Department of Internal Medicine, College of Medicine, Wonkwang University)
Jung, Jong-Hoon (Department of Internal Medicine, College of Medicine, Wonkwang University)
Kim, Hwi-Jung (Department of Internal Medicine, College of Medicine, Wonkwang University)
Yang, Sei-Hoon (Department of Internal Medicine, College of Medicine, Wonkwang University)
Jeong, Eun-Taik (Department of Internal Medicine, College of Medicine, Wonkwang University)
Publication Information
Tuberculosis and Respiratory Diseases / v.57, no.5, 2004 , pp. 443-448 More about this Journal
Abstract
Background : Small-cell carcinomas of lung have a tendency for rapid growth and early wide metastasis. Despite the high response rates of combination chemotherapy alone or with radiotherapy, the overall long-term survival rate is very disappointing. According to autopsy findings, the common cause of failure is local recurrence in the primary cancer site. Therefore, surgical resection with combined chemotherapy has recently been attempted for very early stage small-cell carcinomas of the lung. Methods : 10 patients (TNM I & II: 5 cases each) undergoing surgical resection for small-cell carcinomas of the lung were treated with adjuvant chemotherapy in an attempt to prolong survival. Of these, 9 patients received chemotherapy, and a retrospective study for survival undertaken (Kaplan-Meier analysis). Results : The median survival time was 26 months, and the 2- and 5-year survival rates were 68.6 and 46.7%, respectively. If the 1 patient not having undergone chemotherapy was excluded, the 2-, 5-year survival rates were 76.2 and 50.8%, respectively? No difference in the survival rate was seen between patients with TNM stages I and II. Conclusion : Adjuvant chemotherapy after surgical resection results in prolonged survival for patients with TNM stages I and II small-cell carcinomas of the lung.
Keywords
Small-cell lung carcinoma; Operation; Chemotherapy; Survival;
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