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Recurrent Secondary Pneumothorax Caused by Bronchiolitis Obliterans Due to Chronic Graft Versus Host Disease in a Patient with Chronic Myelogenous Leukemia after Allogenic Bone Marrow Transplantation  

Ahn, Chul Min (Department of Internal Medicine, Yonsei University College of Medicine)
Hwang, Sang Yun (Department of Internal Medicine, Yonsei University College of Medicine)
Byun, Min Kwang (Department of Internal Medicine, Yonsei University College of Medicine)
Lee, Jin Hyoung (Department of Internal Medicine, Yonsei University College of Medicine)
Chung, Wou Young (Department of Internal Medicine, Yonsei University College of Medicine)
Moon, Jin Wook (Department of Internal Medicine, Yonsei University College of Medicine)
Park, Moo Suk (Department of Internal Medicine, Yonsei University College of Medicine)
Min, Yoo Hong (Department of Internal Medicine, Yonsei University College of Medicine)
Kim, Se Kyu (Department of Internal Medicine, Yonsei University College of Medicine)
Chang, Joon (Department of Internal Medicine, Yonsei University College of Medicine)
Kim, Sung Kyu (Department of Internal Medicine, Yonsei University College of Medicine)
Kim, Haeryoung (Department of Pathology, Yonsei University College of Medicine)
Kim, Hoguen (Department of Pathology, Yonsei University College of Medicine)
Kim, Young Sam (Department of Internal Medicine, Yonsei University College of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.57, no.2, 2004 , pp. 183-187 More about this Journal
Abstract
Bronchiolitis obliterans (BO) is a nonspecific inflammatory injury affecting primarily the small airways. Its inflammatory process is characterized by fibrotic obliteration of the lumen of bronchioles. BO can be idiopathic or associated with connective tissue disease, inhaled toxins, infections, drugs, and chronic graft-versus-host-disease (GVHD). Pulmonary complications occur in 40~60% of patients who undergo allogeneic bone marrow transplantation (BMT), causing 10~40% of transplant-related deaths. BO is a characteristic pulmonary complication which occurs usually within a few years after BMT. Documented complications of BO include air-leak syndromes such as pneumomediastinum, subcutaneous emphysema and pneumothorax. We report a case of a 30-year-old male patient with BO due to chronic GVHD after allogenic BMT who presented with recurrent bilateral pneumothoraces.
Keywords
Bone marrow transplantation; Bronchiolitis obliterans; Graft-versus-host-disease; Pneumothorax; air-leak syndrome;
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1 Clark JG, Crawford SW, Madtes DK, Sullivan KM. Obstructive lung disease after allogeneic marrow transplantation. Clinical presentation and course. Ann Intern Med 1989;111:368-76
2 Jegal YJ, Lee JH, Lee GH, Kim UG, Shim TS, Im CM, et al. Lung complications after allergenic bone marrow transplantation. Tuberc Respir Dis 2000;49: 207-16
3 Yokoi T, Hirabayashi N, Ito M, Uno Y, Tsuzuki T, Yatabe Y, et al. Broncho- onchiolitis obliterans as a complication of bone marrow transplantation: a clini copathological study of eight autopsy cases. Virchows Arch 1997;431:275-82
4 Yousem SA. The histological spectrum of pulmonary graft-versus-host disease in bone marrow transplant recipients. Hum Pathol 1995;26:668-75
5 Marras TK, Chan CK, Lipton JH, Messner HA, Sza lai JP, Laupacis A. Long-term pulmonary function abnormalities and survival after allogeneic marrowtransplantation. Bone Marrow Transplant 2004;33: 509-17
6 Johnson FL, Stokes DC, Ruggiero M, Dalla-Pozza L, Callihan TR. Chronic obstructive airways disease after bone marrow transplantation. J Pediatr 1984;105:370-6
7 Nysom K, Holm K, Hesse B, Ulrik CS, Jacobsen N, Bisgaard H, et al. Lung function after allogeneic bone marrow transplantation for leukemia or lym phoma. Arch Dis Child 1996;74:432-6
8 Galanis E, Litzow MR, Tefferi A, Scott JP. Spontaneous pneumomediastinum in a patient with bron chiolitis obliterans after bone marrow transplantation. Bone Marrow Transplant 1997;20:695-6
9 Meyers JD, Flournoy N, Thomas ED. Nonbacterial pneumonia after allogeneic bone marrow transplantation : A review of ten years’ experience. Rev In fect Dis 1982;4:1119-32
10 Payne L, Chan CK, Fyles G, Hyland RH, Bafundi P, Yeung M, et al. Cyclosporine as possible prophylaxis for obstructive airways disease after allogeneic bone marrow transplantation. Chest 1993;104:114-8
11 Benesch M, Kerbl R, Schwinger W, Lackner H, Pfleger A, Popper H, et al. Discrepancy of clinical, radio graphic and histopathologic findings in two childrenwith chronic pulmonary graft-versus-host disease after HLA-identical sibling stem cell transplantation. Bone Marrow Transplant 1998;22:809-12
12 Suzuki T, Saijo Y, Ebina M, Yaekashiwa M, Minegi shi M, Tsuchiya S, et al. Bilateral pneumothoraces with multiple bullae in a patient with asymptomatic bronchiolitis obliterans 10 years after bone marrow transplantation. Bone Marrow Transplant 1999;23: 829-31
13 Kumar S, Tefferi A. Spontaneous pneumomediastinum and subcutaneous emphysema complicating bronchiolitis obliterans after allogenic bone marrow transplanta tion-case report and review of the literature. Ann Hematol 2001;80:430-5
14 Wyatt SE, Nunn P, Hows JM, Yin J, Hayes MC, Catovsky D, et al. Airways obstruction associated with graft versus host disease after bone marrow transplantation. Thorax 1984;39:887-94
15 Curtis DJ, Smale A, Thien F, Schwarer AP, Szer J. Chronic airflow obstruction in long-term survivors of allogeneic bone marrow transplantation. Bone Marrow Transplant 1995;16:169-73