Browse > Article

A Case of Pellagra Induced by Isoniazid during Treatment of Pulmonary Tuberculosis  

Jeon, Ho Seok (Department of Internal Medicine, Eulji University School of Medicine)
Han, Min Soo (Department of Internal Medicine, Eulji University School of Medicine)
Ahn, Ju Eui (Department of Internal Medicine, Eulji University School of Medicine)
Lee, Yang Deok (Department of Internal Medicine, Eulji University School of Medicine)
Cho, Yongseon (Department of Internal Medicine, Eulji University School of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.57, no.2, 2004 , pp. 180-182 More about this Journal
Abstract
A Case of Pellagra Induced by Isoniazid during Treatment of Pulmonary Tuberculosis Pellagra is a disease caused by a deficiency of nicotinic acid or niacin. It is mostly found among people eating corn-based diets in parts of China, Africa and India. It is also induced by drugs, such as isoniazid or 5-fluorouracil. Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients. Pellagra should be suspected whenever tuberculous patients under the treatment with isoniazid develop mental, neurological or gastrointestinal symptoms, even in the absence of typical skin changes. Herein, our experienced of a case of pellagra induced by isoniazid during treatment of pulmonary tuberculosis is reported. The patient was referred due to a skin rash and drowsy mental status. Her skin lesion developed during treatment for pulmonary tuberculosis. Her symptoms were improved after discontinuation of antituberculous agents and on the administration of nicotinamide.
Keywords
Pellagra; Isoniazid; Pulmonary tuberculosis;
Citations & Related Records

Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 Darvay A, Basarab T, McGregor JM, Russell-Jones R. Isoniazid induced pellagra despite pyridoxine supplementation. Clin Exp Dermatol 1999 May;24(3): 167-9
2 Stevens HP, Ostlere LS, Begent RH, Dooley JS, Rustin MH. Pellagra secondary to 5-fluorouracil. Br J Dermatol 1993 May;128(5):578-80
3 McConnell RB, Cheetham HD. Acute pellagra during isoniazid therapy. Lancet 1952 Nov 15;2(20):959-60
4 Bender DA, Russell-Jones R. Isoniazid-induced pellagra despite vitamin-B6 supplementation. Lancet 1979 Nov 24;2(8152):1125-6
5 Burke GJ, Hlangabeza T. Isoniazid-induced pellagra in a patient on vitamin B supplement. S Afr Med J 1977 May 14;51(20):719
6 Harrington CI. A case of pellagra induced by isoniazid therapy. Practitioner 1977 May;218(1307):716-7
7 Meyrick Thomas RH, Rowland Payne CM, Black MM. Isoniazid-induced pellagra. Br Med J (Clin Res Ed) 1981 Jul 25;283(6286):287-8
8 Ishii N, Nishihara Y. Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy. J Neurol Neurosurg Psychiatry 1985 Jul;48(7):628-34