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Aspirin Reduces Acute Lung Injury in Rats Subjected to Severe Hemorrhage  

Shin, Tae Rim (Department of Internal Medicine, Catholic University of Daegu)
Lee, Dong Uk (Department of Physiology, Catholic University of Daegu)
Park, Yoon-Yub (Department of Physiology, Catholic University of Daegu)
Publication Information
Tuberculosis and Respiratory Diseases / v.54, no.5, 2003 , pp. 522-531 More about this Journal
Abstract
Background : Hemorrhagic shock and trauma are two of the most common causes of acute lung injury. The activation of cyclooxygenase is one of the important causes of acute lung injury. This study investigated the effect of aspirin, a well-known cyclooxygenase inhibitor, on severe hemorrhage-induced acute lung injury in rats. Methods : The hemorrhagic shock was induced by withdrawing blood; 20ml/kg of B.W., through the femoral artery in 5 min. The mean arterial pressure was recorded through the femoral artery on a polygraph. Results : In the present investigation, the lung tissue myeloperoxidase activity, protein contents and leukocyte counts, in bronchoalveolar lavage fluid, increased significantly 2 and 24 h after the hemorrhage induction. Although the decreased mean arterial pressure spontaneously recovered, acute lung injury occurred after severe hemorrhage. These changes were effectively prevented by a single intravenous injection of aspirin (10 mg/kg of B.W.) 30 min before the hemorrhage. Conclusion : These results suggest that severe hemorrhage-induced acute lung injury is mediated, in part, by the activation of cyclooxygenase. Furthermore, pretreatment of aspirin in acute lung injury-prone patients, or prophylactic treatment of aspirin to the patients with precipitating conditions, could be helpful in the prevention of acute lung injury.
Keywords
Hemorrhage; Acute lung injury; Aspirin; Cyclooxygenase;
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