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A Case of Severe Bleomycin-Induced Pneumonitis at Non-Hodgkin's Lymphoma  

Han, Dong-Ha (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine)
Min, Young-Joo (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine)
Yoon, Je-Hyun (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine)
Park, Jong-Ho (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine)
Ahn, Jong-Joon (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine)
Lee, Ki-Man (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine)
Park, Jae-Hoo (Department of Internal Medicine, Ulsan University Hospital University of Ulsan College of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.52, no.3, 2002 , pp. 260-264 More about this Journal
Abstract
Bleomycin-induced pulmonary toxicity usually occurs in the elderly patients (greater than 70 years old), patients with a cumulative dose above 400 units, previous chest radiotherapy, oxygen therapy, and renal failure. However, there are some reports of severe pneumonitis that developed after administering low bleomycin doses(less than 100 units). In severe bleomycin-induced pneumonitis in non-Hodgkin's lymphoma patients, the response to corticosteroid is poor and the mortality rate is very high, approximately 83%. Therefore, clinicians should have a low threshold for investigating and treating bleomycin-induced pneumonitis. Here, we report a case of severe bleomycin-induced pneumonitis as a complication of a non-Hodgkin's lymphoma treatment.
Keywords
Non-Hodgkin's lymphoma; Bleomycin; Pulmonary toxicity;
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