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http://dx.doi.org/10.11620/IJOB.2020.45.4.218

Antitumor effects of octyl gallate on hypopharyngeal carcinoma cells  

NTK, Trang (Department of Pharmacology and Dental Therapeutics, College of Dentistry, Chosun University)
Yoo, Hoon (Department of Pharmacology and Dental Therapeutics, College of Dentistry, Chosun University)
Publication Information
International Journal of Oral Biology / v.45, no.4, 2020 , pp. 218-224 More about this Journal
Abstract
The antitumor effects of octyl gallate (OG) were investigated on FaDu human hypopharyngeal squamous carcinoma cells. At various concentrations, OG inhibited the proliferation of FaDu cells by suppressing cell cycle regulators and induced apoptosis by activating caspase 3 and its downstream poly (ADP-ribose) polymerase, thereby damaging DNA. Immunoblotting demonstrated that OG significantly suppressed the expression of integrin family proteins (integrin α4, αv, β3, β4), hindering cell adhesion. The reduced expression of integrins subsequently mediated the mitogen-activated protein kinase signaling pathway to stimulate the activation of extracellular signal-regulated kinases and c-jun N-terminal kinases, leading to apoptosis. Thus, OG demonstrated antitumor activity on hypopharyngeal squamous carcinoma cells by suppressing cell proliferation and inducing apoptosis.
Keywords
Pharyngeal squamous cell carcinoma; Octyl gallate; Apoptosis; Mitogen-activated protein kinase signaling pathway; Integrins;
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