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http://dx.doi.org/10.11620/IJOB.2019.44.1.27

Clinical evaluation of cetylpyridinium chloride-containing mouthwash in halitosis  

Kang, Minkyung (Dong-A Pharmaceutical Research Laboratories)
Kim, Boyeon (Dong-A Pharmaceutical Research Laboratories)
Park, Hyounggeun (Dong-A Pharmaceutical Research Laboratories)
Lee, Eunseok (Dong-A Pharmaceutical Research Laboratories)
Publication Information
International Journal of Oral Biology / v.44, no.1, 2019 , pp. 27-29 More about this Journal
Abstract
Halitosis is a very common disease that affects the majority of the population and is characterized by unpleasant odor during expiration. Anaerobic bacteria produce a range of malodorous substances including volatile sulfur compounds. To reduce oral malodor, the amount of oral microorganisms should be managed through brushing, scraping, and use of antibacterial agents. In this study, a mouthwash containing 0.05% cetylpyridinium chloride was tested on 22 candidates with oral malodor for two weeks to confirm oral malodor reduction through the use of antibacterial mouthwashes. Volatile sulfur compound measurements were significantly lower after using the mouthwash than before using it; thus, the mouthwash effectively reduced oral malodor.
Keywords
Halitosis; Bacteria; Sterilization; Mouth;
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1 Tangerman A. Halitosis in medicine: a review. Int Dent J 2002;52 Suppl 3:201-6. doi: 10.1002/j.1875-595X.2002.tb00925.x.   DOI
2 Seerangaiyan K, van Winkelhoff AJ, Harmsen HJM, Rossen JWA, Winkel EG. The tongue microbiome in healthy subjects and patients with intra-oral halitosis. J Breath Res 2017;11:036010. doi: 10.1088/1752-7163/aa7c24.   DOI
3 Tangerman A, Winkel EG. Extra-oral halitosis: an overview. J Breath Res 2010;4:017003. doi: 10.1088/1752-7155/4/1/017003.   DOI
4 Quirynen M, Dadamio J, Van den Velde S, De Smit M, Dekeyser C, Van Tornout M, Vandekerckhove B. Characteristics of 2000 patients who visited a halitosis clinic. J Clin Periodontol 2009;36:970-5. doi: 10.1111/j.1600-051X.2009.01478.x.   DOI
5 Seemann R, Duarte da Conceicao M, Filippi A, Greenman J, Lenton P, Nachnani S, Quirynen M, Roldan S, Schulze H, Sterer N, Tangerman A, Winkel EG, Yaegaki K, Rosenberg M. [Halitosis management by the general dental practitioner-results of an International Consensus Workshop]. Swiss Dent J 2014;124:1205-11. German. doi: 10.1088/1752-7155/8/1/017101.
6 Kazor CE, Mitchell PM, Lee AM, Stokes LN, Loesche WJ, Dewhirst FE, Paster BJ. Diversity of bacterial populations on the tongue dorsa of patients with halitosis and healthy patients. J Clin Microbiol 2003;41:558-63. doi: 10.1128/JCM.41.2.558-563.2003.   DOI
7 Kang JH, Kim DJ, Choi BK, Park JW. Inhibition of malodorous gas formation by oral bacteria with cetylpyridinium and zinc chloride. Arch Oral Biol 2017;84:133-8. doi: 10.1016/j.archoralbio.2017.09.023.   DOI
8 Hughes FJ, McNab R. Oral malodour--a review. Arch Oral Biol 2008;53 Suppl 1:S1-7. doi: 10.1016/S0003-9969(08)70002-5.   DOI
9 Pitts G, Pianotti R, Feary TW, McGuiness J, Masurat T. The in vivo effects of an antiseptic mouthwash on odor-producing microorganisms. J Dent Res 1981;60:1891-6. doi: 10.1177/00220345810600111101.   DOI
10 Liu J, Ling JQ, Wu CD. Cetylpyridinium chloride suppresses gene expression associated with halitosis. Arch Oral Biol 2013;58:1686-91. doi: 10.1016/j.archoralbio.2013.08.014.   DOI
11 Renton-Harper P, Addy M, Moran J, Doherty FM, Newcombe RG. A comparison of chlorhexidine, cetylpyridinium chloride, triclosan, and C31G mouthrinse products for plaque inhibition. J Periodontol 1996;67:486-9. doi: 10.1902/jop.1996.67.5.486.   DOI
12 Feres M, Figueiredo LC, Faveri M, Guerra MC, Mateo LR, Stewart B, Williams M, Panagakos F. The efficacy of two oral hygiene regimens in reducing oral malodour: a randomised clinical trial. Int Dent J 2015;65:292-302. doi: 10.1111/idj.12183.   DOI
13 Mandel ID. Chemotherapeutic agents for controlling plaque and gingivitis. J Clin Periodontol 1988;15:488-94. doi: 10.1111/j.1600-051X.1988.tb01020.x.   DOI
14 European Commission. Scientific Committee on Consumer Products: opinion on cetylpyridinium chloride. Brussels: European Commission; 2006 Mar. SCCP/0985/06. 5 p.
15 Sreenivasan PK, Haraszthy VI, Zambon JJ. Antimicrobial efficacy of $0{\cdot}05%$ cetylpyridinium chloride mouthrinses. Lett Appl Microbiol 2013;56:14-20. doi: 10.1111/lam.12008.   DOI