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http://dx.doi.org/10.11620/IJOB.2017.42.3.085

The Relationship between Mitochondria and NLRP3 Inflammasome  

Lee, Hyun Ah (Department of Oral Microbiology, School of Dentistry, Pusan National University)
Na, Hee Sam (Department of Oral Microbiology, School of Dentistry, Pusan National University)
Chung, Jin (Department of Oral Microbiology, School of Dentistry, Pusan National University)
Publication Information
International Journal of Oral Biology / v.42, no.3, 2017 , pp. 85-90 More about this Journal
Abstract
Mitochondria participate in various intracellular metabolic pathways such as generating intracellular ATP, synthesizing several essential molecules, regulating calcium homeostasis, and producing the cell's reactive oxygen species (ROS). Emerging studies have demonstrated newly discovered roles of mitochondria, which participate in the regulation of innate immune responses by modulating NLRP3 inflammasomes. Here, we review the recently proposed pathways to be involved in mitochondria-mediated regulation of inflammasome activation and inflammation: 1) mitochondrial ROS, 2) calcium mobilization, 3) nicotinamide adenine dinucleotide ($NAD^+$) reduction, 4) cardiolipin, 5) mitofusin, 6) mitochondrial DNA, 7) mitochondrial antiviral signaling protein. Furthermore, we highlight the significance of mitophagy as a negative regulator of mitochondrial damage and NLRP3 inflammasome activation, as potentially helpful therapeutic approaches which could potentially address uncontrolled inflammation.
Keywords
Mitochondria; NLRP3 inflammasome; Innate immune response;
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